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Fundamentals of Cardiac T1 Mapping

  • Joëlle K. Barral
  • Matthias G. Friedrich
  • Nikola Stikov
Chapter

Abstract

In the first chapter, entitled Fundamentals of Cardiac T1 Mapping, we present an overview of the scientific principles, technical choices and challenges associated with cardiac T1 mapping. This chapter reminds the reader that T1 mapping relies on a physical model of the MR signal, and shows the ways in which this model breaks down when the underlying assumptions are not met.

We start from first principles and introduce the basics of body T1 mapping before moving onto the most widely used cardiac sequences: MOLLI and ShMOLLI (which are based on a Look-Locker sequence) and SASHA (based on a saturation recovery sequence). We take a particularly close look at the confounding factors that might impact T1 mapping results in practice.

Next, we give key insights into the T1 mapping post-processing techniques, which are often used to communicate T1 mapping results to radiologists and cardiologists. Finally, we emphasize the need for proper validation, provide suggestions for standardizing the field, and end the chapter with recommendations for the clinical application of cardiac T1 mapping.

Keywords

Pulse sequences Quantitative MRI T1 mapping (Sh)MOLLI SASHA 

Notes

Acknowledgements

The authors would like to thank Pascale Beliveau and Tarik Hafyane for their help with preparing the figures, and Reeve Ingle for insightful discussions.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Joëlle K. Barral
    • 1
  • Matthias G. Friedrich
    • 2
  • Nikola Stikov
    • 3
    • 4
  1. 1.Verily Life SciencesSouth San FranciscoUSA
  2. 2.Departments of Cardiology and Diagnostic RadiologyMcGill University Health Centre, McGill UniversityMontrealCanada
  3. 3.NeuroPoly LabInstitute of Biomedical Engineering, Polytechnique MontrealMontrealCanada
  4. 4.Montreal Heart Institute, University of MontrealMontrealCanada

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