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Chemical Digestion, Absorption, and Transport

  • Menizibeya Osain Welcome
Chapter

Abstract

Chemical digestion involves the catalytic processing of food in the gastrointestinal (GI) tract by digestive enzymes, aided by co-secreted substances, required to break down the food substances into simpler molecules for absorption. This process is necessary for transport and subsequent metabolic reactions that access the macroergic bonds in food molecules. The catalytic process of digestion starts from the mouth for lipids and carbohydrates. For proteins, the catalytic process begins from the stomach. The sources of the enzymes and co-secreted factors are the glands lining the GI tract, namely salivary, submucosal, gastric, and intestinal glands. This chapter provides up-to-date information on the course of discovery as well as the discoverers of major digestive enzymes in humans. The functions and mechanisms of action of all major digestive enzymes discovered up to the twenty-first century are discussed herein. This chapter is a useful reference source on the history and discovery of major digestive enzymes and the mechanisms of regulation of their functions. The clinical importance of the enzymes is systematically provided at strategic points of the discussion. This chapter provides cellular and molecular mechanisms on the absorption and transport of nutrients, ions, dietary elements, vitamins, toxic metals, and pharmacological drugs in the gut. Pathological implications of some of the components of GI metabolism are strategically outlined.

Keywords

Chemical processing of food Chemical digestion Catalysis Carbohydrate Lipid Fatty acids Protein Amino acids Protease Pepsin Trypsin Chymotrypsin Duodenase Enterokinase Carbohydrase Amylase Lipase Lingual lipase Gastric lipase Pancreatic lipase Colipase Alpha-glucosidases Maltase-glucoamylase Sucrase-isomaltase Lactase-phlorizin hydrolase Trehalase Disaccharidases Succus entericus Trypsin inhibitor Trypsin receptor SWEET Glucose chansporter TGA resynthesis Chylomicrons Basolateral exocytosis Lipid absorption Dietary elements’ gut epithelial ion transport Calcium absorption and transport Iron absorption and transport Magnesium absorption and transport Zinc absorption and transport Metal absorption and transport Anion absorption and transport Toxic metal absorption and transport Pharmacological drug Vitamin absorption and transport Water-soluble vitamins Lipid-soluble vitamins Bile acids Enterohepatic recirculation Water absorption and transport Cystic fibrosis Pancreatic hyperenzymemia Gullo’s syndrome Variant pancreatic ducts Pancreatic ductal system Alexander Mixailovich Ugolev Alexander Yakovlevich (Jakulovich) Danilevsky or Alexander Jakulowitsch Danilewsky Anselme Payen Apollinaire Bouchardat Claude Bernard Erhard Friedrich Leuchs Gabriel Gustav Valentin Hans Henriksen Ussing Horace Middleton Vernon Jacques Loeb James Batcheller Sumner Jean-François Persoz Johann Nepomuk Eberle Johannes Bohn John Howard Northrop Julius Wohlgemuth Lucio Gullo Moses Kunitz Nikolas Petrovich Shepovalnikov Robert Robison Roger moss Herriott Rudolf P. H. Heidenhain Sigmund Rosenheim Otto Theodor Schwann Wendell Meredith Stanley Willy Kühne (Wilhelm Friedrich Kühne) Zamolodchikova Tatyana Stepanovna 

Abbreviations

5HT1B

5-Hydroxytryptamine type 1B

Asp

Aspartate

BACE-1

Beta-site APP-cleaving enzyme-1

Ca2+

Calcium ion

CCK

Cholecystokinin

CD

Cluster of differentiation

CLPS

Colipase

CNS

Central nervous system

COX-1 & -2

Cyclooxygenases-1 and 2

CT

Computer tomography

Cu2+

Copper ion

Cys

Cystine

F1-ATPase

F-type of adenosine triphosphate enzyme

HCl

Hydrochloric acid

Hg2+

Mercury ion

kDa

Kilodalton

kg

Kilogram

mEq/L

Milliequivalent per liter

mg/dl

Milligram per deciliter

mL

Milliliter

mmol

Millimole

NBT-PABA

N-benzoyl-l-tyrosyl-p-aminobenzoic acid

NSAID

Non-steroid anti-inflammatory drug

PGs

Prostaglandins

SCFA

Short-chain fatty acids

α

Alpha

β

Beta

γ

Gamma

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