I Can “See” Clearly Now

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang


A 16-year-old woman with sickle cell disease now presents with aplastic crisis with a hematocrit (Hct) of 17% (the patient’s baseline Hct is 28%). The patient has been transfused many times with the last red blood cell (RBC) transfusion occurring 1 month ago. The patient has a known history of anti-E antibody. A sample (ethylenediaminetetraacetic acid [EDTA] anticoagulant) is submitted to the blood bank for stat type and screen with request for two RBC units.


Delayed hemolytic transfusion reaction Hemolytic disease of the fetus/newborn Rh antibodies Sickle cell disease 


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Recommended Reading

  1. Klein HG, Anstee DJ. The Rh blood group system (including LW and RHAG). In: Klein HG, Anstee DJ, editors. Mollison’s blood transfusion in clinical medicine. 12th ed. West Sussex: Wiley; 2014. p. 197.CrossRefGoogle Scholar
  2. Leger RM. The positive direct antiglobulin test and immune-mediated hemolysis. In: Fung MK, Grossman BJ, Hillyer CD, Westhoff CM, editors. Technical manual. 18th ed. Bethesda: AABB; 2014. p. 425.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

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