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Passengers and Hitchhikers

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang
Chapter

Abstract

A 54-year-old woman with hepatitis C cirrhosis, status post deceased-donor orthotopic liver transplant 14 days ago, returns for outpatient follow-up with complaints of excessive fatigue, lightheadedness, and dyspnea on exertion. The patient had experienced an uneventful postoperative course and was discharged from the hospital in good condition on postoperative day #4. Laboratory studies show that the hemoglobin (Hgb) has decreased from 9.1 (hospital discharge) to 5.1 g/dL. A type and screen sample (ethylenediaminetetraacetic acid [EDTA] anticoagulant) and a request for two units of red blood cells (RBCs) are submitted to the blood bank.

Keywords

Liver transplant Passenger lymphocyte syndrome Rh antibodies 

References

  1. 1.
    Peck JR, Elkhammas EA, Li F, Stanich PP, Latchana N, Black S, Michaels A. Passenger lymphocyte syndrome: a forgotten cause of postliver transplant jaundice and anemia. Exp Clin Transplant 2015;13(2):200–202.Google Scholar
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    De Bruijn S, Philipse E, Couttenye MM, Bracke B, Ysebaert D, Michielsenet P, et al. Passenger lymphocyte syndrome (PLS): a single-center retrospective analysis of minor ABO-incompatible liver transplants. J Clin Transl Hepatol. 2017;5(1):9–15.CrossRefPubMedPubMedCentralGoogle Scholar
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    Cserti-Gazdewich CM, Waddell TK, Singer LG, Chaparro C, Pendergrast JM, Hawes J, et al. Passenger lymphocyte syndrome with or without immune hemolytic anemia in all Rh-positive recipients of lungs from rhesus alloimmunized donors: three new cases and a review of the literature. Transfus Med Rev. 2009;23(2):134–45.CrossRefPubMedGoogle Scholar

Recommended Reading

  1. Cserti-Gazdewich CM, Waddell TK, Singer LG, Chaparro C, Pendergrast JM, Hawes J, et al. Passenger lymphocyte syndrome with or without immune hemolytic anemia in all Rh-positive recipients of lungs from rhesus alloimmunized donors: three new cases and a review of the literature. Transfus Med Rev. 2009;23(2):134–45.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

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