A 27-year-old woman with a history of sickle cell disease is admitted with pain crisis (pain in extremities and back) and possible sepsis. The patient, who has a history of anti-Fya and anti-S alloantibodies, has had several admissions to the hospital for pain crisis over the past 5 years. She was transfused two units of red blood cells (RBCs) 1 year ago and received RBC exchange transfusion (six units) for acute chest syndrome 2 years ago; all RBCs were matched by extended phenotype (C-, E-, K-negative) as per the blood bank’s policy for sickle cell patients. A type and screen sample (ethylenediaminetetraacetic acid, EDTA anticoagulant) is submitted to the blood bank.
Anti-Fya antibody Anti-S antibody Duffy blood group Evanescence Hyperhemolysis syndrome MNS blood group S antigen
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