Hey, How Did That Antibody Get There?

  • Mark T. Friedman
  • Kamille A. West
  • Peyman Bizargity
  • Kyle Annen
  • Jeffrey S. Jhang


A 33-year-old woman with a history of sickle cell disease is admitted with pain crisis (pain in extremities and back). The patient, who has no history of antibodies, has had several admissions to the hospital for pain crisis over the past 3 years and was transfused one unit of red blood cells (RBCs) 2 years ago; the RBCs were matched by extended phenotype (negative for C, E, and K antigens) as per your blood bank’s policy for sickle cell patients. The patient denies receiving any RBC transfusions since the one unit given 2 years ago at the hospital. A type and screen sample (ethylenediaminetetraacetic acid [EDTA] anticoagulant) is submitted to the blood bank.


Anti-K antibody Extended antigen matching Kell blood group Matuhasi–Ogata phenomenon Rh blood group Sickle cell 


  1. 1.
    Bove JR, Holburn AM, Mollison PL. Non-specific binding of IgG to antibody-coated red cells (the ‘Matuhasi–Ogata phenomenon’). Immunology. 1973;25(5):793–801.PubMedPubMedCentralGoogle Scholar
  2. 2.
    Viggiano E, Clary NL, Ballas SK. Autoanti-K antibody mimicking an alloantibody. Transfusion. 1982;22(4):329–32.CrossRefGoogle Scholar
  3. 3.
    Yazdanbakhsh K, Ware RE, Noizat-Pirenne F. Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion. Blood. 2012;120(3):528–37.CrossRefGoogle Scholar
  4. 4.
    Redman M, Regan F, Contrares M. A prospective study of the incidence of red cell allo-immunisation following transfusion. Vox Sang. 1996;71:216–20.CrossRefGoogle Scholar

Recommended Reading

  1. Miller ST, Kim HY, Weiner DL, Investigators of the Sickle Cell Disease Clinical Research Network (SCDCRN), et al. Red blood cell alloimmunization in sickle cell disease: prevalence in 2010. Transfusion. 2013;53(4):704–9.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mark T. Friedman
    • 1
  • Kamille A. West
    • 2
  • Peyman Bizargity
    • 3
  • Kyle Annen
    • 4
  • Jeffrey S. Jhang
    • 1
  1. 1.Icahn School of MedicineMount Sinai Health SystemNew YorkUSA
  2. 2.Department of Transfusion MedicineNational Institutes of Health Clinical CenterBethesdaUSA
  3. 3.Department of Molecular & Human GeneticsBaylor College of MedicineHoustonUSA
  4. 4.Department of PathologyChildren’s Hospital ColoradoAuroraUSA

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