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Antibody Mediated Rejection: Are We There Yet?

  • Glen P. Westall
  • Lucy C. Sullivan
Chapter

Abstract

The diagnosis, management and treatment of antibody-mediated rejection (AMR) following lung transplantation remains challenging, but is associated with both acute and chronic lung allograft dysfunction (CLAD). Confidence for the diagnosis of AMR increases according to how many of the diagnostic tenets are present that include anti-HLA donor specific antibodies (DSA), C4d staining and histological changes centered around the capillary septum. Future studies on pulmonary AMR will be facilitated by the recent publication of a consensus statement on AMR in lung transplantation.

Keywords

Lung transplantation Antibody-mediated rejection (AMR) Donor specific antibodies (DSA) Humoral rejection Chronic lung allograft dysfunction (CLAD) 

Notes

Acknowledgments

The Alfred’s Lung Transplant Service gratefully acknowledges the Lungitude Foundation for their research and education support.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Lung Transplant ServiceAlfred Hospital and Monash UniversityMelbourneAustralia
  2. 2.Department of Microbiology and ImmunologyThe University of Melbourne at The Peter Doherty Institute for Infection and ImmunityMelbourneAustralia

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