Lung Transplantation for Interstitial Lung Disease

  • Monique Anne MaloufEmail author


This chapter aims to review the need for lung transplantation for interstitial lung diseases in particular for idiopathic pulmonary fibrosis (IPF), which often fails to respond to medical therapy. The American Thoracic Society recognizes that supplemental oxygen and transplantation are the only suggested treatments for IPF. Prognosis of IPF is generally poor, retrospective cohort studies indicate a median survival of 2–3 years from diagnosis and only 20–30% survive 5 years after diagnosis. Consequently patients with this condition are at increased risk of mortality and lung transplantation offers hope to patients, who are found to be suitable after careful selection for this life saving procedure. Over the past 2–3 decades significant improvements in long term survival and quality of life have been demonstrated. However survival after lung transplantation remains significantly shorter than survival reported in other solid organ transplants (SOT) due to chronic lung allograft dysfunction (CLAD) and infection.



The author is grateful to the anatomical department of St. Vincent’s hospital for graciously providing anatomical histology of the various interstitial lung diseases required for this chapter.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.The Lung Transplant Unit Xavier Level 4St. Vincent’s HospitalDarlinghurstAustralia

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