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Fertility Preservation in the Male Adolescent Patient

  • Ron Golan
  • James A. Kashanian
Chapter

Abstract

Over 15,000 children develop cancer in the United States (US) each year (Ward et al., CA Cancer J Clin 64(2):83–103, 2014), with a 5-year survival rate for childhood cancer being roughly 80% (Robison and Hudson, Nat Rev Cancer 14(1):61–70, 2014). This extrapolates to over 385,000 childhood cancer survivors living in the United States (Phillips et al., Cancer Epidemiol Biomark Prev 24(4):653–663, 2015). With a growing number of childhood cancer survivors, oncologic counseling has seen a shift in focus from concentrating solely on short- and long-term survival benefits of treatment regimens to survivorship and long-term effects of treatments. With this shifting paradigm, short- and long-term gonadotoxic effects of cancer treatment have become a major concern for clinicians treating and patients diagnosed with malignancies. Because of this, fertility preservation (FP) among adolescent and young adult (AYA) cancer patients has become a significant area of interest and research.

In this chapter, we will discuss FP management options, outcomes, and expectations in the AYA patient population. Questions that will be addressed include barriers to FP, attitudes and perspectives of cancer survivors, short- and long-term effects of cancer treatment on spermatogenesis, quality of sperm in the setting of localized or systemic malignancies, optimal timing for FP, conventional and experimental options for FP, and utilization of sperm banked.

Keywords

Fertility Fertility preservation Oncofertility Sperm banking Tissue cryopreservation Gonadotoxicity 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of UrologyWeill Cornell MedicineNew YorkUSA

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