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Heat Shock Proteins in Oxidative and Nitrosative Stress

  • Kattaia Asmaa A. A. A. 
  • Abd El-Baset Samia A. 
  • Eman M. Mohamed
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 15)

Abstract

Multiple human pathologies have been attributed to oxidative/nitrosative stress. Stress occurs when the production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) exceeds the antioxidant capacity. Heat shock proteins (HSP) are closely related families of constitutively expressed and stress-induced cellular proteins that protect cellular homeostasis against heat and other stress stimuli. Oxidative stress is considered a key mediator of HSP induction. This chapter reviews the role of Hsp70 in different disorders associated with oxidative/nitrosative stress with reference to factors affecting Hsp70 gene expression, the role of proteasomes, the anti-apoptotic and anti-inflammatory effects and the relation between heat stress and oxidative stress. Moreover, we address the overexpression of other HSP such as Hsp32, 27, 40 and 60 following oxidative/nitrosative stress.

Keywords

Heat shock proteins Hsp70 Nitrosative stress NO Oxidative stress 

Abbreviations

Ag NP

Silver nanoparticles

ARE

Antioxidant responsive element

HBA

Heat shock protein 90-binding agent

HO-1

Heme oxygenase-1

HSE

Heat shock elements

HSF

Heat shock factor

HSP

Heat shock proteins

I/R

Ischemia/reperfusion

iNOS or NOS II

Inducible nitric-oxide synthase

NF-κB

Nuclear factor kappa beta

NO

Nitric oxide

NOS I/PKG

Nitric-oxide synthase I/ protein kinase G

ONHs

Optic nerve heads

RNS

Reactive nitrogen species

ROS

Reactive oxygen species

RVLM

Rostral ventrolateral medulla

TNF

Tumor necrosis factor

Notes

Acknowledgements

The authors would like to thank the support from Histology and Cell Biology Department, Faculty of Medicine, Zagazig University. We also thank many lab members and colleagues for critical and productive collaborations.

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Kattaia Asmaa A. A. A. 
    • 1
  • Abd El-Baset Samia A. 
    • 1
  • Eman M. Mohamed
    • 1
  1. 1.Department of Histology and Cell Biology, Faculty of MedicineZagazig UniversityZagazigEgypt

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