Relationship between Oxidative Stress-Induced Effects and Physical Exercise

  • Hyunseok Jee
Part of the Heat Shock Proteins book series (HESP, volume 15)


This chapter focuses on various agents that induce intracellular oxidative stress within the cell environment, the roles of heat shock proteins (HSP) within such harsh cellular environments, and the relationship between HSP and the exercises used to alleviate the negative effects of oxidative stress in the living body. The keywords used in this study, such as the origin of oxidative stress, HSP, and exercise, will provide scientists insights into the optimized exercise-induced adaptation for minimizing the pathological effects of oxidative stress. This study can provide important clues to design optimized exercise programs, which can produce maximal effects against the cellular damages caused by oxidative stress.


Antioxidants Exercise Heat shock protein Oxidative stress Stress 



This study was supported by the Ministry of Education and the National Research Foundation of Korea (NRF-2015S1A5B8036349). I would like to thank God for helping me complete this article.


  1. Asea AA (2007) Release of heat shock proteins: passive versus active release mechanisms. In: Heat shock proteins: potent mediators of inflammation and immunity Springer. Springer, Dordrecht, pp 3–20CrossRefGoogle Scholar
  2. Atlay M, Oksala NK, Laaksonen DE, Khanna S, Nakao C, Lappalainen J, Roy S, Hänninen O, Sen CK (2004) Exercise training modulates heat shock protein response in diabetic rats. J Appl Physiol 97:605–611CrossRefGoogle Scholar
  3. Battie C, Jutsukawa S, Bernerd F, Del Bino S, Marionnet C, Verschoore M (2014) New insights in photoaging, UVA induced damage and skin types. Exp Dermatol 23:7–12CrossRefGoogle Scholar
  4. Bonorino C, Souza AP (2007) Hsp70 in tumors: friend or foe? In: Heat shock proteins in cancer. Springer, pp 191–208Google Scholar
  5. Brune B (1991) Oxidative stress in platelets. In: Oxidative stress, Oxidants and antioxidants, pp 421–443Google Scholar
  6. Chang BD, Broude EV, Dokmanovic M, Zhu H, Ruth A, Xuan Y, Kandel ES, Lausch E, Christov K, Roninson IB (1999a) A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res 59:3761–3767PubMedGoogle Scholar
  7. Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J, Roninson IB (1999b) Role of p53 and p21 waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene 18:4808CrossRefGoogle Scholar
  8. Chang CK, Chang CP, Liu SY, Lin MT (2007) Oxidative stress and ischemic injuries in heat stroke. Prog Brain Res 162:525–546CrossRefGoogle Scholar
  9. Cotto JJ, Morimoto RI (1999) Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors. Biochem Society Symposia JSTORGoogle Scholar
  10. Dimauro I, Mercatelli N, Caporossi D (2016) Exercise-induced ROS in heat shock proteins response. Free Radic Biol Med 98:46–55CrossRefGoogle Scholar
  11. Fehrenbach E, Northoff H (2001) Free radicals, exercise, apoptosis, and heat shock proteins. Exerc Immunol Rev 7:66–89PubMedGoogle Scholar
  12. Garner M, Garner W, Spector A (1982) The effect of H2O2 on Na/K ATPase. Invest Ophthalmol Vis Sci 22:34Google Scholar
  13. Giblin FJ, McCready JP, Schrimscher L, Reddy VN (1987) Peroxide-induced effects on lens cation transport following inhibition of glutathione reductase activity in vitro. Exp Eye Res 45:77–91CrossRefGoogle Scholar
  14. Hamilton KL, Staib JL, Philips T, Hess A, Lennon SL, Powers SK (2003) Exercise, antioxidants, and HSP72: protection against myocardial ischemia/reperfusion. Free Radic Biol Med 34:800–809CrossRefGoogle Scholar
  15. Huffman DM, Moellering DR, Grizzle WE, Stockard CR, Johnson MS, Nagy TR (2008) Effect of exercise and calorie restriction on biomarkers of aging in mice. Am J Physiol Regul Integr Comp Physiol 294:R1618–R1627CrossRefGoogle Scholar
  16. Jackson MJ (2011) Control of reactive oxygen, species production in contracting skeletal muscle. Antioxid Redox Signal 15:2477–2486CrossRefGoogle Scholar
  17. Jee H (2016) Size dependent classification of heat shock proteins: a mini-review. J Exerc Rehabil 12:255CrossRefGoogle Scholar
  18. McArdle A, Pattwell D, Vasklaki A, Griffiths R, Jackson M (2001) Contractile activity-induced oxidative stress: cellular origin and adaptive responses. Am J Physiol Cell Physiol 280:C621–C627CrossRefGoogle Scholar
  19. Mlitz V, Gendronneau G, Berlin I, Buchberger M, Eckhard L, Tschachler E (2016) The expression of the endogenous mTORC1 inhibitor sestrin 2 is induced by UVB and balanced with the expression level of sestrin 1. PLoS One 11:e0166832CrossRefGoogle Scholar
  20. Nishisgori C (2015) Current concept of photocarcinogenesis. Photochem Photobiol Sci 14:1713–1721CrossRefGoogle Scholar
  21. Njemini R, Bautmans I, Lambert M, Demanet C, Mets T (2007) Heat shock proteins and chemokine/cytokine secretion profile in ageing and inflammation. Mech Ageing Dev 128:450–454CrossRefGoogle Scholar
  22. Ock CY, Kim EH, Choi DJ, Lee HJ, Hahm KB, Chung MH (2012) 8-Hydroxydeoguanosine: not mere biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal disease. World J Gastroenterol:WJG 18:302CrossRefGoogle Scholar
  23. Patwell DM, MrArdle A, Morgan JE, Patridge TA, Jackson MJ (2004) Release of reactive oxygen and nitrogen species from contracting skeletal muscle cells. Free Radic Biol Med 37:1064–1072CrossRefGoogle Scholar
  24. Powers SK, Duarte J, Kavazis AN, Talbert EE (2010) Reactive oxygen species are signalling molecules for skeletal muscle adaptation. Exp Physiol 95:1–9CrossRefGoogle Scholar
  25. Sagai M, Bocci V (2011) Mechanisms of action involved in ozone therapy: is healing induced via a mild oxidative stress? Med Gas Res 1:29CrossRefGoogle Scholar
  26. Samali A, Orrenius S (1998) Heat shock proteins: regulators of stress response and apoptosis. Cell Stress Chaperones 3:228CrossRefGoogle Scholar
  27. Sanchis-Gomar F (2013) Sestrins: novel antioxidant and AMPK-modulating functions regulated by exercise? J Cell Physiol 228:1647–16550CrossRefGoogle Scholar
  28. Semenkov VF, Michalski AI, Sapozhnikov AM (2015) Heating and ultraviolet light activate anti-stress gene functions in humans. Front Genet 6Google Scholar
  29. Sherman M, Yaglom J (2007) Role of molecular chaperones in cell senescence. In: Heat shock proteins in cancer, pp 159–168CrossRefGoogle Scholar
  30. Sies H (1991) Oxidative stress: oxidants and antioxidants. Academic Pr Google Scholar
  31. Sova H, Jukkola-Vuorinen A, Puistola U, Kauppila S, Karihtala P (2010) 8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer. Br J Cancer 102:1018CrossRefGoogle Scholar
  32. Spector A (1991) The lens and oxidative stress. In: Oxidative stress, oxidants and antioxidants, pp 529–558Google Scholar
  33. Vasilaki A, Csete M, Pye D, Lee S, Palomero J, McArdle F, Van Remmen H, Richardson A, McArdle A, Faulkner J (2006a) Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting skeletal muscle cells. Free Radic Biol Med 41:1719–1725CrossRefGoogle Scholar
  34. Vasilaki A, McArdle F, Iwaneijko L, McArdle A (2006b) Adaptive responses of mouse skeletal muscle to contractile activity: the effect of age. Mech Ageing Dev 127:830–839CrossRefGoogle Scholar
  35. Ziemann E, Zembroñ-Lacny A, Kasperska A, Antosiewicz J, Grzywacz T, Garsztka T, Laskowski R (2013) Exercise training-induced changes in inflammatory mediators and heat shock proteins in young tennnis players. J Sports Sci Med 12:282PubMedPubMedCentralGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Hyunseok Jee
    • 1
  1. 1.Frontier Research Institute of Convergence Sports Science (FRICSS)Yonsei UniversitySeoulRepublic of Korea

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