Stem Cells and Cancer

  • Meredith Davis
  • Katja Gassner
  • Ruth Rodriguez-Barrueco
  • David Llobet-NavasEmail author


The plasticity of cancer stem cells (CSCs) is one of the greatest challenges in cancer therapeutics. CSCs not only foster tumour development, but they also activate mechanisms of tumour immune surveillance evasion, metabolic reprogramming, and metastatic colonization. The clinical significance of CSCs involves their resistance to chemotherapy and their major role in tumour relapse after treatment. Mechanisms that are essential for the induction, maintenance, and survival of CSCs are ambiguous. A deeper understanding of what triggers CSCs, and helps them survive and spread, will provide insight into new treatment strategies in the field of clinical oncology. 


Cancer stem cells 



ATP-binding cassette


Antibody-drug conjugate


Aldehyde dehydrogenase 1


Acute lymphoblastic leukaemia


Acute myeloid leukaemia


B-cell lymphoma-2


Chronic myeloid leukaemia


Cancer stem cell


Dynamin-related protein 1


Epithelial-mesenchymal transition


Embryonic stem cell


Glioma stem cell


Hypoxia-inducible factor


Head and neck squamous cell carcinoma


Haematopoietic stem cell


Induced pluripotent stem cell


Leukemic stem cell


Mesenchymal-epithelial transition




Mitochondrial DNA


Oxidative phosphorylation


Pyruvate kinase muscle


Pyruvate dehydrogenase kinase 1


Reactive oxygen species


Transcription factor


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Meredith Davis
    • 1
  • Katja Gassner
    • 1
    • 2
  • Ruth Rodriguez-Barrueco
    • 1
    • 2
    • 3
  • David Llobet-Navas
    • 1
    • 2
    Email author
  1. 1.Institute of Genetic Medicine, Newcastle UniversityNewcastle upon TyneUK
  2. 2.Bellvitge Biomedical Research Institute (IDIBELL)Gran via de l’Hospitalet, 199L’Hospitalet de LlobregatSpain
  3. 3.Universitat de Barcelona, Facultat de Medicina i Ciències de la Salut. Departament d’Anatomia i Terapèutica Experimental. Bellvitge Biomedical Research Institute (IDIBELL), Gran via de l’Hospitalet, 199Universitat de Barcelona, Facultat de Medicina i Ciències de la SalutL’Hospitalet de LlobregatSpain

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