Reflux and Aspiration: Their Presumed Role in Chronic Cough and the Development of End-Stage Lung Disease

  • Jacob A. Klapper
  • Brian Gulack
  • Matthew G. HartwigEmail author


Amongst patients with end-stage lung disease (ESLD), symptoms and diagnostic evidence of gastroesophageal reflux disease (GERD) are extremely common. In fact, roughly two-thirds of all patients with ESLD have documentable gastroesophageal reflux [1]. The presence of significant reflux is not limited to one pulmonary disease, but is seen in patients with ESLD secondary to COPD, cystic fibrosis and idiopathic pulmonary fibrosis (IPF) [2] (Gasper et al. 2007). While the pathophysiology of COPD and cystic fibrosis are well understood, it remains unknown what leads to the eventual development of IPF. Interestingly, evidence has continued to mount over the last 20 years that reflux is not just prevalent in patients with IPF, but may in fact be contributing to its development.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Jacob A. Klapper
    • 1
  • Brian Gulack
    • 1
  • Matthew G. Hartwig
    • 1
    Email author
  1. 1.Division of Cardiovascular and Thoracic Surgery, Department of SurgeryDuke University Medical CenterDurhamUSA

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