Thymic Neoplasm

  • Mirella MarinoEmail author
  • Francesco Facciolo
  • Yan Shen
  • Gabriele Alessandrini
  • Nicolas Girard
Part of the Current Clinical Pathology book series (CCPATH)


The variety of tumors originating in the thymus partially reflects the main cellular types present in the organ, i.e., epithelial and lymphoid cells. However, in the anterior mediastinum along with the thymus, several other structures and ectopic tissues are located, giving rise to a variety of other tumors. The clinical, pathological, and genetic features of thymic epithelial tumors are described, together with the key imaging features supporting the diagnosis. A review of current surgical options is provided, as well as current chemotherapeutic and targeted agent treatment options. The added value of international networks (ERN, European reference networks) is discussed with respect to patient care.


Thymic epithelial tumors Thymoma Thymic carcinoma Pathology Genetics Imaging Surgery Chemotherapy Targeted agents Networks 



The authors want to thank Pr G. Palmieri (Naples, Italy) for her longstanding collaboration and Dr. Enzo Gallo for his photographical and editorial overview.

The authors are also grateful to Dr. T. Merlino for English language editing.

No funding was received for this work.

Conflict of Interest Statement

MM, FF, YS, and GA declare no conflict of interest. Nicolas Girard has received research support and travel grants from Novartis, Bristol-Myers Squibb, MSD, and Pfizer.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mirella Marino
    • 1
    Email author
  • Francesco Facciolo
    • 2
  • Yan Shen
    • 3
  • Gabriele Alessandrini
    • 2
  • Nicolas Girard
    • 4
    • 5
    • 6
  1. 1.Department of PathologyRegina Elena National Cancer InstituteRomeItaly
  2. 2.Department of Thoracic SurgeryRegina Elena National Cancer InstituteRomeItaly
  3. 3.Department of RadiologyShanghai Chest Hospital, Shanghai Jiao Tong UniversityShanghaiChina
  4. 4.University of Lyon, University Claude Bernard LyonLyonFrance
  5. 5.Hospices Civils de LyonLyonFrance
  6. 6.Institut du Thorax Curie Montsouris, Institut CurieParisFrance

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