Thymic Tumors and Lymphomas: The Clinical Impact of Their Underlying Molecular Features

  • Francesca PentimalliEmail author
  • Daniela Barone
  • Antonio Giordano
Part of the Current Clinical Pathology book series (CCPATH)


Although rare, mediastinal tumors often present a challenge for both the physicians and the pathologists. Here we focus on the molecular features underlying thymic tumors and lymphomas, which are the most common malignancies occurring in the anterior compartment of the mediastinum. We discuss both established and recently discovered molecular alterations that can overall serve as diagnostic, prognostic, and predictive factors or possibly as targets for therapeutic intervention.


Thymic epithelial tumors Thymomas Thymic carcinoma Lymphoma Diffuse large B-cell lymphoma (DLBCL) Primary mediastinal large B-cell lymphoma (PMLBCL) Classical Hodgkin lymphoma (cHL) Mediastinal gray zone lymphoma (MGZL) 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Francesca Pentimalli
    • 1
    Email author
  • Daniela Barone
    • 1
  • Antonio Giordano
    • 2
    • 3
  1. 1.Oncology Research Center of Mercogliano (CROM), Istituto Nazionale Tumori-IRCCS-Fondazione G. PascaleNaplesItaly
  2. 2.Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, College of Science and Technology, Temple UniversityPhiladelphiaUSA
  3. 3.Department of Medicine, Surgery and NeuroscienceUniversity of SienaSienaItaly

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