Mediastinal masses include a wide variety of entities both neoplastic and not often presenting with several clinical and pathological features thus constituting a diagnostic challenge for clinicians.
In about half of cases, a mediastinal mass can be an incidental finding in patients who undergo imaging studies for other reasons.
Local symptoms, if present, may be due to compressive or infiltrative effects of the mass, while systemic symptoms are due to release of hormones, cytokines, and antibodies. In general, malignant lesions are more likely to be symptomatic.
In most patients, a combination of demographic information, clinical presentation, and imaging features allows a presumptive diagnosis, which can be definitely addressed only after tissue biopsy.
Mediastinal Mass Superior vena cava Myasthenia gravis
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Priola AM, Priola SM, Cardinale L, et al. The anterior mediastinum: diseases. Radiol Med. 2006;111(3):312–42.CrossRefGoogle Scholar
Kim Y, Lee KS, Yoo JH, et al. Middle mediastinal lesions: imaging findings and pathologic correlation. Eur J Radiol. 2000;35(1):30–8.CrossRefGoogle Scholar
Occhipinti M, Heidinger BH, Franquet E, et al. Imaging the posterior mediastinum: a multimodality approach. Diagn Interv Radiol. 2015;21(4):293–306.CrossRefGoogle Scholar
Davis RD Jr, Oldham HN Jr, Sabiston DC Jr. Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management, and results. Ann Thorac Surg. 1987;44(3):229–37.CrossRefGoogle Scholar
Wilson LD, Detterbeck FC, Yahalom J. Superior vena cava syndrome with malignant causes. N Engl J Med. 2007;356:1862–9.CrossRefGoogle Scholar
Cohen R, Mena D, Carbajal-Mendoza R, et al. Superior vena cava syndrome: a medical emergency? Int J Angiol. 2008;17(1):43–6.CrossRefGoogle Scholar
Shelly S, Levin NA, Altman A, et al. Thymoma and autoimmunity. Cell Mol Immunol. 2011;8(3):199–202.CrossRefGoogle Scholar
Azarow KS, Pearl RH, Zurcher R, et al. Primary mediastinal masses: a comparison of adult and pediatric populations. J Thorac Cardiovasc Surg. 1993;106:67.PubMedGoogle Scholar
Barlow LJ, Badalato GM, McKiernan JM. Serum tumor markers in the evaluation of male germ cell tumors. Nat Rev Urol. 2010;7(11):610–7.CrossRefGoogle Scholar
Takahashi K, Al-Janabi NJ. Computed tomography and magnetic resonance imaging of mediastinal tumors. J Magn Reson Imaging. 2010;32(6):1325–39.CrossRefGoogle Scholar
Gupta S, Seaberg K, Wallace MJ, et al. Imaging-guided percutaneous biopsy of mediastinal lesions: different approaches and anatomic considerations. Radiographics. 2005;25(3):763–86.CrossRefGoogle Scholar