Abstract
Neurogenic tumours of the thorax commonly occur at the posterior mediastinum and affect children and young adults. They currently represent 15–20% of all mediastinal tumours and are benign in most adults in contrast with children where the malignancy rate is as high as 50%. These tumours originate from embryonic neural crest cells and from sympathetic or parasympathetic ganglia. They are generally asymptomatic and discovered most frequently incidentally. Malignant neurogenic tumours are more likely to produce symptoms. Management is complete surgical excision either by open or minimally invasive procedures which offer definite diagnosis and cure.
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References
Ronson RS, Duarte I, Miller JI. Embryology and surgical anatomy of the mediastinum with clinical implications. Surg Clin North Am. 2000;80:157–69, x–xi.
Fujimoto K, Hara M, Tomiyama N, et al. Proposal for a new mediastinal compartment classification of transverse plane images according to the Japanese Association for Research on the Thymus (JART) General Rules for the Study of Mediastinal Tumors. Oncol Rep. 2014;31:565–72.
Pansky B. Review of medical embryology. New York: Macmillan; 1982. p. 135–81.
Duwe BV, Sterman DH, Musani AI. Tumors of the mediastinum. Chest. 2005;128:2893–909.
Reeder LB. Neurogenic tumors of the mediastinum. Semin Thorac Cardiovasc Surg. 2000;12:261–7.
Takeda S, Miyoshi S, Minami M, Matsuda H. Intrathoracic neurogenic tumors—50 years’ experience in a Japanese institution. Eur J Cardiothorac Surg. 2004;26(4):807–12.
Strollo DC, Rosado-de-Christenson ML, Jett JR. Primary mediastinal tumors: part II. Tumors of the middle and posterior mediastinum. Chest. 1997;112:1344–57.
Jaggers J, Balsara K. Mediastinal masses in children. Semin Thorac Cardiovasc Surg. 2004;16:201–8.
Wain JC. Neurogenic tumors of the mediastinum. Chest Surg Clin N Am. 1992;2:121–36.
Nakajima Y, Mikami I, Akiyama H, Kinoshita H, Iijima Y, Uramoto H. Long-term progress of six cases of malignant peripheral nerve sheath tumors of the mediastinum that underwent surgical treatment: case report series. Int J Surg Case Rep. 2016;24:185–7.
Ducatman BS, Scheithauer BW, Piepgras DG, Reiman HM, Ilstrup DM. Malignant peripheral nerve sheath tumors. A clinicopathologic study of 120 cases. Cancer. 1986;57(10):2006–21.
Lonergan GJ, Schwab CM, Suarez ES, Carlson CL. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 2002;22(4):911–34.
Reed JC, Hallet KK, Feigen DS. Neural tumors of the thorax: subject review from the AFIP. Radiology. 1978;126:9.
Hoover EL, et al. Neuroblastoma. A rare primary intrathoracic neurogenic tumor in adults. Tex Heart Inst J. 1988;15:107.
Lee JY, Lee KS, Han J, et al. Spectrum of neurogenic tumors in the thorax: CT and pathologic findings. J Comput Assist Tomogr. 1999;23:399–406.
Nakazono T, White CS, Yamasaki F, Yamaguchi K, Egashira R, Irie H, Kudo S. MRI findings of mediastinal neurogenic tumors. AJR Am J Roentgenol. 2011;197(4):W643–52.
Adam A, Lizellote H. Ganglioneuroblastoma of the posterior mediastinum: a clinicopathologic review of 80 cases. Cancer. 1981;47(2):373–81.
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Mueller I, Schweigerer L, Berthold F, Hero B. Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed. BMC Cancer. 2016;16:542.
Yang C, Zhao D, Zhou X, Ding J, Jiang G. A comparative study of video-assisted thoracoscopic resection versus thoracotomy for neurogenic tumours arising at the thoracic apex. Interact Cardiovasc Thorac Surg. 2015;20:35–40.
Heltzer JM, Krasna MJ, Aldrich F, McLaughlin JS. Thoracoscopic excision of a posterior mediastinal “dumbbell” tumor using a combined approach. Ann Thorac Surg. 1995;60:431–3.
Liu H-P, Yim APC, Wan J, Chen H, Yi-Cheng W, Liu Y-H, Lin PJ, Chang C-H. Thoracoscopic removal of intrathoracic neurogenic tumors: a combined Chinese experience. Ann Surg. 2000;232(2):187–90.
Melfi F, Fanucchi O, Davini F, Viti A, Lucchi M, Ambrogi MC, Mussi A. Ten-year experience of mediastinal robotic surgery in a single referral centre. Eur J Cardiothorac Surg. 2012;41:847–51.
Alrabeeah A, et al. Neurenteric cysts—a spectrum. J Pediatr Surg. 1988;23:752.
Fallon M, Gordon ARG, Lendrum AC. Mediastinal cysts of foregut origin associated with vertebral abnormalities. Br J Surg. 1954;41:520.
Rescorla FJ, et al. Efficacy of primary and secondary video-assisted thoracic surgery in children. J Pediatr Surg. 2000;51:134.
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Konstantinidis, K., Papagiannopoulos, K. (2018). Nerve Sheath Tumours, Ganglion Tumours and Neurenteric Cysts. In: Franco, R., Zito Marino, F., Giordano, A. (eds) The Mediastinal Mass. Current Clinical Pathology. Humana, Cham. https://doi.org/10.1007/978-3-319-90368-2_17
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DOI: https://doi.org/10.1007/978-3-319-90368-2_17
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