Granulomatous Disease

  • Nicola MartucciEmail author
  • Giuseppe De Luca
  • Gaetano Rocco
Part of the Current Clinical Pathology book series (CCPATH)


Granulomatous disease of the mediastinum is a particular pathological condition characterized by the formation of granulomas in mediastinal lymph nodes. Mediastinal granuloma is the abnormal enlargement of mediastinal lymph nodes by granulomatous inflammation, is usually asymptomatic or minimally symptomatic, and is often detected on chest radiographs taken for other reasons.

Clinical manifestations may be due to superior vena cava (SVC) obstruction, esophageal compression, large airway involvement, pulmonary artery or pulmonary vein narrowing, or laryngeal or phrenic nerve impingement. Definitive diagnosis is traditionally made on the basis of a cytological exam or surgical exploration and biopsy, either a mediastinoscopy or thoracotomy.


Mediastinal granuloma Mediastinal granulomatosis 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Nicola Martucci
    • 1
    Email author
  • Giuseppe De Luca
    • 1
  • Gaetano Rocco
    • 1
  1. 1.Division of Thoracic Surgery, Thoracic DepartmentIstituto Nazionale Tumori, IRCCS, Fondazione PascaleNaplesItaly

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