Introduction (Epidemiology, Mediastinal Anatomy, Mediastinal Masses)

  • Gerardo BottiEmail author
  • Federica Zito Marino
Part of the Current Clinical Pathology book series (CCPATH)


Mediastinal masses are relatively uncommon and affect patients of all ages. They are generally asymptomatic and only approximately one third of mediastinal tumors cause symptoms. Mediastinal masses include a wide variety of tumors that often have overlapping histologic features, representing an interesting diagnostic and therapeutic challenge. They may arise from anterior, middle, or posterior mediastinum, and in this context the location and composition of a mass are critical to narrowing the differential diagnosis.


Mediastinal anatomy Anterior mediastinal masses Middle mediastinal masses Posterior mediastinal masses 


  1. 1.
    Wright CD, Mathisen DJ. Mediastinal tumors: diagnosis and treatment. World J Surg. 2001;25:204–9.CrossRefGoogle Scholar
  2. 2.
    Fraser RS, Pare JA, Fraser RG, et al. The normal chest. In: Fraser RS, Pare JA, Fraser RG, et al., editors. Synopsis of diseases of the chest. 2nd ed. Philadelphia: W.B. Saunders; 1994. p. 1–116.Google Scholar
  3. 3.
    Fraser RS, Muller NL, Colman N, et al. The mediastinum. In: Fraser RS, Muller NL, Colman N, et al., editors. Fraser and Pare’s diagnosis of diseases of the chest. 4th ed. Philadelphia: W.B. Saunders; 1999. p. 196–234.Google Scholar
  4. 4.
    Aroor AR, Prakasha SR, Seshadri S, Teerthanath S, Raghuraj U. A study of clinical characteristics of mediastinal mass. J Clin Diagn Res. 2014;8:77–80.PubMedPubMedCentralGoogle Scholar
  5. 5.
    Davis RD, Oldham HN, Sabiston DC. Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management, and results. Ann Thorac Surg. 1987;44:229.CrossRefGoogle Scholar
  6. 6.
    Asgary MR, Aghajanzadeh M, Hemmati H, Jafari M. Epidemiology of mediastinal tumors during six years (2006-2012) in Rasht city. Acta Med Mediterranea. 2016;32:1243.Google Scholar
  7. 7.
    Almeida FA, Kane GC. Approach to mediastinal masses. Pulmon Dis. 2007;12:2–13.Google Scholar
  8. 8.
    Duwe BV, Sterman DH, Musani AI. Tumors of the mediastinum. Chest. 2005;128:2893–909.CrossRefGoogle Scholar
  9. 9.
    Strickler JG, Kurtin PJ. Mediastinal lymphoma. Semin Diagn Pathol. 1991;8:2–13.PubMedGoogle Scholar
  10. 10.
    Reeder LB. Neurogenic tumors of the mediastinum. Semin Thorac Cardiovasc Surg. 2000;12:261–7.CrossRefGoogle Scholar

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Scientific DirectionIstituto dei Tumori ‘Fondazione G. Pascale’NaplesItaly
  2. 2.Pathology Unit, Department of Mental and Physic Health and Preventive MedicineUniversità della Campania ‘Luigi Vanvitelli’NaplesItaly

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