Cerebral Vascular Injury in Diabetic Ischemia and Reperfusion

  • Wenlu Li
  • Haibin DaiEmail author
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


About 30% of stroke patients are diabetic and more than 90% of them comprise type 2 diabetes (T2D). Diabetic stroke patients have higher mortality and worse neurological outcomes. Emerging clinical and experimental data suggest that blood-brain barrier (BBB) disruption, neuroinflammation, and stroke recovery impairment are exacerbated in diabetic patients. Hence, finding therapeutic approaches that can target these specific diabetic mechanisms in stroke is the thrust of the present translational study. Here, we summarize the ischemia-reperfusion injury in stroke, presenting the clinical evidence for involvement of hyperglycemia in severe damage of cerebral ischemia-reperfusion. We go on to consider the mechanisms that underlie such pathology, and highlight areas for future basic research and clinical studies into diabetic ischemia and reperfusion.


Vascular Cerebral ischemia-reperfusion Stroke Diabetes 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina

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