RBD in Childhood and Adolescence
While REM sleep behavior disorder (RBD) is typically observed among older adults, with characteristic clinical and polysomnographic features and risk for future neurodegenerative disease in the majority, it has also been reported among children and adolescents. The clinical presentation, associated conditions, and clinical course have not been studied in detail in childhood, however. Insights into the pathogenesis, clinical manifestations, diagnosis and directions for future research related to childhood-onset RBD and its polysomnographic signature, REM sleep without atonia (RSWA), are presented. An illustrative case report has been included, and details of published case reports and case series have been tabulated. Differential diagnosis and clues for recognition of RBD among the young are also discussed.
KeywordsChildhood RBD Polysomnography REM without atonia Narcolepsy Brainstem tumors Antidepressant medications
- 1.Partinen M, Hublin C. Epidemiology of sleep disorders. In: Kryger MH, Roth T, Dement WC, editors. Principles and practice of sleep medicine. Philadelphia: WB Saunders; 2000. p. 558–79.Google Scholar
- 14.Schenck CH, Bundlie SR, Smith SA, Ettinger MG, Mahowald MW. REM behavior disorder in a 10 year old girl and aperiodic REM and NREM sleep movements in an 8 year old brother. Sleep Res. 1986;15:162.Google Scholar
- 17.Blaw ME, Leroy RF, Steinberg JB, Herman J. Hereditary quivering chin and REM behavioral disorder. Ann Neurol. 1989;26:471.Google Scholar
- 18.Herman JH, Blaw ME, Steinberg JB. REM behavior disorder in a two year old male with evidence of brainstem pathology. Sleep Res. 1989;18:242.Google Scholar
- 22.Turner R, Allen WT. REM sleep behavior disorder associated with narcolepsy in an adolescent: a case report. Sleep Res. 1990;19:302.Google Scholar
- 27.American Academy of Sleep Medicine. International classification of sleep disorders. 3rd ed. Darien: American Academy of Sleep Medicine; 2014.Google Scholar
- 31.Berry RB, Brooks R, Gamaldo CE, Harding SM, Lloyd RM, Marcus CL and Vaughn BV for the American Academy of Sleep Medicine. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, Version 2.3. Darien: American Academy of Sleep Medicine; 2016. www.aasmnet.org.