Combination Therapy

  • Mio NakamuraEmail author
  • Caleb Jeon
  • John Koo
Part of the Updates in Clinical Dermatology book series (UCD)


Psoriasis is a chronic inflammatory skin disease with a remitting and relapsing course. Long-term remission can be difficult to achieve regardless of severity of psoriasis. Using two or more therapies with varying mechanisms of action and safety profiles is often necessary to maintain adequate disease control while minimizing toxicity of treatments. Choosing a combination regimen that maximizes safety and efficacy, while at the same time considers patient usability and compliance, can be difficult. Presently, numerous treatment options are available for the treatment of psoriasis including topical agents, phototherapy, oral systemic agents, and biologics, with many more therapeutic agents in the pipeline. With the increasing number of available therapies, there are many opportunities to combine various therapies. It is crucial for clinicians to carefully consider the fine balance between safety and efficacy when combining various therapeutic agents and utilize strategies such as rotational therapy and sequential therapy when appropriate. This chapter will review various combination therapy strategies for the treatment of psoriasis.


Psoriasis Combination therapy Rotational therapy Sequential therapy 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Dermatology, Psoriasis and Skin Treatment CenterUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Department of Dermatology, UCSF Psoriasis CenterUniversity of California San FranciscoSan FranciscoUSA

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