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The Future of Personality Research and Applications: Some Latest Findings

  • Danilo Garcia
  • Kevin M. Cloninger
  • Nigel Lester
  • C. Robert Cloninger
Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

Human personality, although highly complex, is crucial to understand because it is the strongest predictor of our physical, mental, and social health as well as the actual cause of most mortality and chronic disease. However, despite the fact that earlier twin studies have found that the differences between people in personality are about 50% heritable, until recently only about 1% of this heritability has been explained by specific genes. Here we briefly outline current notions about the genetics of personality and also describe recent research that used novel and innovative person-centered methods to identify nearly all the genes for human personality. This international collaboration among 27 investigators at multiple sites comprised data from the Young Finns Study in Finland with independent replications in Germany and Korea (Zwir et al., Mol Psychiatry, 2018a, 2018b). In short, these results now make it possible to understand the basic mechanisms that influence our emotions as well as the way we can self-regulate our feelings, goals, and values in order to live healthy and satisfying lives. What is even more, these results provide a foundation for a thorough understanding of the complex molecular and brain processes that regulate human health and well-being. In this line, we also present preliminary results of a recent pilot study, in which interventions targeting character development among Swedish young adults suggest improvements in well-being after 6 months of well-being coaching. Importantly, it is argued that character regulates the expression of temperament predispositions, so character is the regulator of well-being regardless of underlying temperament. That is, since we are body, mind, and psyche at once (i.e., biopsychosocial in nature), the person needs to learn to both know and understand her temperament and her character to integrate them in order to adapt intelligently to who she is and the changing circumstances in the world around her.

Keywords

Anthropedia well-being training Character Coaching Genetics Personality Person-centered methods Temperament 

Notes

Acknowledgments

The authors are especially grateful to Peter Ratcovich and FINSAM (http://finsam-blekinge.se/index.php?page=1) for the grant that allowed us to conduct the project “Rehabilitation through Cultural Activities and Person-Centered Well-Being Coaching.” We direct our gratitude also to Anna Andersson, project leader, for facilitating the data collection and to Erik Lindskär for his assistance with data collection and the preliminary analysis for Fig. 4a, b.

References

  1. Ando, J., Suzuki, A., Yamagata, S., Kijima, N., Maekawa, H., Ono, Y., & Jang, K. L. (2004). Genetic and environmental structure of Cloninger’s temperament and character dimensions. Journal of Personality Disorders, 18, 379–393.  https://doi.org/10.1521/pedi.18.4.379.40345CrossRefPubMedGoogle Scholar
  2. Arnedo, J., del Val, C., de Erausquin, G. A., Romero-Zaliz, R., Svrakic, D., Cloninger, C. R., & Zwir, I. (2013). PGMRA: A web server for (phenotype × genotype) many-to- many relation analysis in GWAS. Nucleic Acids Research, 41(Web Server issue), W142–W149.  https://doi.org/10.1093/nar/gkt496CrossRefPubMedPubMedCentralGoogle Scholar
  3. Arnedo, J., Mamah, D., Baranger, D. A., Harms, M. P., Barch, D. M., Svrakic, D. M., … Zwir, I. (2015). Decomposition of brain diffusion imaging data uncovers latent schizophrenias with distinct patterns of white matter anisotropy. Neuroimage, 120, 43–54.  https://doi.org/10.1016/j.neuroimage.2015.06.083CrossRefPubMedGoogle Scholar
  4. Arnedo, J., Svrakic, D. M., Del Val, C., Romero-Zaliz, R., Hernandez-Cuervo, H., Fanous, A. H., et al. (2015). Uncovering the hidden risk architecture of the schizophrenias: Confirmation in three independent genome-wide association studies. American Journal of Psychiatry, 172, 139–153.CrossRefGoogle Scholar
  5. Anderson, C. B., Joyce, P. R., et al. (2002). The effect of cognitive-behavioral therapy for bulimia nervosa on temperament and character as measured by the temperament and character inventory. Comprehensive Psychiatry, 43, 182–188.CrossRefGoogle Scholar
  6. Borg, J., Andree, B., Soderstrom, H., & Farde, L. (2003). The serotonin system and spiritual experiences. American Journal of Psychiatry, 160, 1965–1969.CrossRefGoogle Scholar
  7. Cervone, D. (2004). The architecture of personality. Psychological Reviews, 111, 183–204.CrossRefGoogle Scholar
  8. Cicchetti, D., & Rogosch, F. A. (1996). Equifinality and multifinality in developmental psychopathology. Development and Psychopathology, 8, 597–600.  https://doi.org/10.1017/S0954579400007318CrossRefGoogle Scholar
  9. Cloninger, C. R. (1986). A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatric Developments, 4, 167–226.PubMedPubMedCentralGoogle Scholar
  10. Cloninger, C. R. (1987). A systematic method for clinical description and classification of personality variants. Archives of General Psychiatry, 44, 573–588.CrossRefGoogle Scholar
  11. Cloninger, C. R. (1994). The genetic structure of personality and learning: A phylogenetic model. Clinical Genetics, 46(1 Spec No), 124–137.CrossRefGoogle Scholar
  12. Cloninger, C. R. (Ed.). (1999). Personality and psychopathology. Washington, D.C.: American Psychiatric Press.Google Scholar
  13. Cloninger, C. R. (2003). Completing the psychobiological architecture of human personality development: temperament, character, and coherence. In U. M. Staudinger & U. E. R. Lindenberger (Eds.), Understanding human development: Dialogues with lifespan psychology (pp. 159–182). London, UK: Kluwer Academic Publishers.CrossRefGoogle Scholar
  14. Cloninger, C. R. (2004). Feeling good: The Science of Well-being. New York, NY: Oxford University Press.Google Scholar
  15. Cloninger, C. R. (2008). The psychobiological theory of temperament and character: Comment on Farmer and Goldberg. Psychological Assessment, 20, 292–304.CrossRefGoogle Scholar
  16. Cloninger, C. R. (2013a). The importance of ternary awareness for overcoming the inadequacies of contemporary psychiatry. Revista de Psiquiatra Clinica, 40(4), 110–113.  https://doi.org/10.1590/S0101-60832013000300006CrossRefGoogle Scholar
  17. Cloninger, C. R. (2013b). What makes people healthy, happy, and fulfilled in the face of current world challenges? Mens Sana Monographs, 11, 16–24.  https://doi.org/10.4103/0973-1229.109288CrossRefPubMedPubMedCentralGoogle Scholar
  18. Cloninger, C. R., & Cloninger, K. M. (2011). Development of instruments and evaluative procedures on contributors to illness and health. The International Journal of Person Centered Medicine, 1(3), 446–455.  https://doi.org/10.5750/ijpcm.v1i3.99CrossRefGoogle Scholar
  19. Cloninger, C. R., & Gilligan, S. B. (1987). Neurogenetic mechanisms of learning: A phylogenetic perspective. Journal of Psychiatric Research, 21, 457–472.CrossRefGoogle Scholar
  20. Cloninger, C. R., Przybeck, T. R., Svrakic, D. M., & Wetzel, R. D. (1994). The Temperament and Character Inventory (TCI): A guide to its development and use. St. Louis, MO: Washington University Center for Psychobiology of Personality.Google Scholar
  21. Cloninger, C. R., Svrakic, D. M., & Przybeck, T. R. (1993). A psychobiological model of temperament and character. Archives of General Psychiatry, 50(12), 975–990.CrossRefGoogle Scholar
  22. Cloninger, C. R., Svrakic, N. M., & Svrakic, D. M. (1997). Role of personality self-organization in development of mental order and disorder. Development and Psychopathology, 9(4), 881–906.CrossRefGoogle Scholar
  23. Cloninger, C. R., & Zwir, I. (2018). What is the natural measurement unit of temperament: Single traits or profiles? Philosophical Transactions of the Royal Society, B: Biological Sciences, 373, 20170163.  https://doi.org/10.1098/rstb.2017.0163CrossRefGoogle Scholar
  24. Cloninger, K. M., Granjard, A., Amato, C., Nima, A. A., Rosenberg, P., Lindskär, E., … Garcia, D. (2019). The health effects of anthropedia’s well-being coaching: A 6-month pilot study among long-term unemployment Swedish young adults (3rd ed.). Paris, France: Biennial International Convention of Psychological Science.Google Scholar
  25. Cloninger, K. M., Lester, N., Muszynski, A., Lindskär, E., Cloninger, C. R., & Garcia, D. (2018). Increases in character development, resilience, and well-being among participants in anthropedia’s well-being coaching training. 30th Association for Psychological Science annual convention. San Francisco, CA, USA.Google Scholar
  26. Cloninger, K. M., Muszynski, A., Lester, N., Nima, A. A., Lindskär, E., Cloninger, C. R., & Garcia, D. (2018). Well-being coaching training: Character, resilience and well-being. 9th European conference on positive psychology. Budapest, Hungary.Google Scholar
  27. Cook, T. B., et al. (2015). Latent infection with Toxoplasma gondii: Association with trait aggression and impulsivity in healthy adults. Journal of Psychiatric Research, 60, 87–94.  https://doi.org/10.1016/j.jpsychires.2014.09.019CrossRefPubMedGoogle Scholar
  28. Corchs, F., Corregiari, F., et al. (2008). Personality traits and treatment outcome in obsessive-compulsive disorder. Revista Brasileira de Psiquiatria, 30, 246–250.CrossRefGoogle Scholar
  29. de Moor, M. H., et al. (2012). Meta-analysis of genome-wide association studies for personality. Molecular Psychiatry, 17, 337–349.  https://doi.org/10.1038/mp.2010.128CrossRefPubMedGoogle Scholar
  30. Diener, E., Emmons, R. A., Larsen, R. J., & Griffin, S. (1985). The satisfaction with life scale. Journal of Personality Assessment, 49, 71–75.CrossRefGoogle Scholar
  31. Eichler, E. E., Flint, J., Gibson, G., Kong, A., Leal, S. M., Moore, J. H., & Nadeau, J. H. (2010). Missing heritability and strategies for finding the underlying causes of complex disease. Nature Reviews. Genetics, 11, 446–450.Google Scholar
  32. Garcia, D., Cloninger, K. M., Sikström, S., Anckarsäter, H., & Cloninger, C. R. (2019). A ternary model of personality: Temperament, character, and identity. In S. Sikström & D. Garcia (Eds.), Statistical semantics: Methods and applications. Cham, Switzerland: Springer.Google Scholar
  33. Garcia, D., Lundström, S., Brändström, S., Råstam, M., Cloninger, C. R., Kerekes, N., … Anckarsäter, H. (2013). Temperament and Character in the Child and Adolescent Twin Study in Sweden (CATSS): Comparison to the general population, and genetic structure analysis. PLoS One, 8(8), e70475.  https://doi.org/10.1371/journal.pone.0070475CrossRefPubMedPubMedCentralGoogle Scholar
  34. Garcia, D., Stråge, A., Lundström, S., Radovic, S., Brändström, S., Råstam, M., … Anckarsäter, H. (2014). Responsibility and cooperativeness are constrained, not determined. Frontiers in Psychology, 5, 308.  https://doi.org/10.3389/fpsyg.2014.00308CrossRefPubMedPubMedCentralGoogle Scholar
  35. Gillespie, N. A., Cloninger, C. R., Heath, A. C., & Martin, N. G. (2003). The genetic and environmental relationship between Cloninger’s dimensions of temperament and character. Personality and Individual Differences, 35, 1931–1946.CrossRefGoogle Scholar
  36. Gusnard, D. A., Ollinger, J. M., Shulman, G. L., Cloninger, C. R., et al. (2003). Persistence and brain circuitry. Proceedings of the National Academy of Sciences of the United States of America, 100, 3479–3484.CrossRefGoogle Scholar
  37. Hinton, G. E., & Salakhutdinov, R. R. (2006). Reducing the dimensionality of data with neural networks. Science, 313, 504–507.  https://doi.org/10.1126/science.1127647CrossRefPubMedGoogle Scholar
  38. Kaasinen, V., Maguire, E. A., Kurki, T., Brück, A., & Rinne, J. O. (2005). Mapping brain structure and personality in late adulthood. Neuroimage, 24, 315–322.CrossRefGoogle Scholar
  39. Keller, M. C., Coventry, W. L., Heath, A. C., & Martin, N. G. (2005). Widespread evidence for non-additive genetic variation in Cloninger’s and Eysenck’s personality dimensions using a twin plus sibling design. Behavior Genetics, 35, 707–721.  https://doi.org/10.1007/s10519-005-6041-7CrossRefPubMedGoogle Scholar
  40. Kjell, O. N. E., Daukantaitė, D., Hefferon, K., & Sikström, S. (2015). The harmony in life scale complements the satisfaction with life scale: Expanding the conceptualization of the cognitive component of subjective well-being. Social Indicators Research.  https://doi.org/10.1007/s11205-015-0903-zCrossRefGoogle Scholar
  41. Lester, N., Garcia, D., Lundström, S., Brändström, S., Råstam, M., Kerekes, N., … Anckarsäter, H. (2016). The genetic structure of the character sub-scales of the temperament and character inventory in adolescence. Annals of General Psychiatry, 15, 10.  https://doi.org/10.1186/s12991-016-0094-2CrossRefPubMedPubMedCentralGoogle Scholar
  42. Mortberg, E., & Andersson, G. (2013). Predictors of response to individual and group cognitive behaviour therapy of social phobia. Psychology and Psychotherapy, 87, 32–43.Google Scholar
  43. Munafo, M. R., & Flint, J. (2011). Dissecting the genetic architecture of human personality. Trends in Cognitive Sciences, 15, 395–400.  https://doi.org/10.1016/j.tics.2011.07.007CrossRefPubMedGoogle Scholar
  44. Raitakari, O. T., et al. (2008). Cohort profile: The cardiovascular risk in Young Finns Study. International Journal of Epidemiology, 37, 1220–1226.  https://doi.org/10.1093/ije/dym225CrossRefPubMedGoogle Scholar
  45. Roberts, B. W., Kuncel, N. R., Shiner, R., Caspi, A., & Goldberg, L. R. (2007). The power of personality. The comparative validity of personality traits, socioeconomic status, and cognitive ability for predicting important life outcomes. Perspectives on Psychological Science, 2, 313–345.  https://doi.org/10.1111/j.1745-6916.2007.00047.xCrossRefPubMedPubMedCentralGoogle Scholar
  46. Rowe, S., Jordan, J., et al. (2010). Dimensional measures of personality as a predictor of outcome at 5-year follow-up in women with bulimia nervosa. Psychiatry Research, 185, 414–420.CrossRefGoogle Scholar
  47. Service, S. K., et al. (2012). A genome-wide meta-analysis of association studies of Cloninger’s temperament scales. Translational Psychiatry, 2, e116.  https://doi.org/10.1038/tp.2012.37CrossRefPubMedPubMedCentralGoogle Scholar
  48. Shiner, R. L., Buss, K. A., McClowry, S. G., Putnam, S. P., Saudino, K. J., & Zentner, M. (2012). What is temperament now? Assessing progress in temperament research on the twenty-fifth anniversary of Goldsmith et al. (1987). Child Development Perspectives, 6, 436–444.  https://doi.org/10.1111/j.1750–8606.2012.00254.xCrossRefGoogle Scholar
  49. Staudinger, U. M., & Lindenberger, U. (Eds.). (2003). Understanding human development: Dialogues with lifespan psychology. London, UK: Kluwer Academic Publishers.Google Scholar
  50. Sung, J., et al. (2006). Healthy twin: A twin-family study of Korea—Protocols and current status. Twin Research and Human Genetics, 9, 844–848.  https://doi.org/10.1375/183242706779462822CrossRefPubMedGoogle Scholar
  51. Svrakic, D. M., Whitehead, C., Przybeck, T. R., & Cloninger, C. R. (1993). Differential diagnosis of personality disorders by the seven factor model of temperament and character. Archives of General Psychiatry, 50, 991–999.CrossRefGoogle Scholar
  52. Tomer, R., & Aharon-Peretz, J. (2004). Novelty seeking and harm avoidance in parkinson’s disease: Effects of asymmetric dopamine deficiency. Journal of Neurology, Neurosurgery, and Psychiatry, 75, 972–975.CrossRefGoogle Scholar
  53. Turner, R. M., Hudson, I. L., Butler, P. H., & Joyce, P. R. (2003). Brain function and personality in normal males. Neuroimage, 19, 1145–1163.CrossRefGoogle Scholar
  54. Uher, J. (2013). Personality psychology: Lexical approaches, assessment methods, and trait concepts reveal only half of the story—Why it is time for a paradigm shift. Integrative Psychological & Behavioral Science, 47, 1–55.  https://doi.org/10.1007/s12124-013-9230-6)CrossRefGoogle Scholar
  55. Uher, J. (2015). Interpreting ‘personality’ taxonomies: Why previous models cannot capture individual- specific experiencing, behaviour, functioning and development. Major taxonomic tasks still lay ahead. Integrative Psychological and Behavioral Science, 49, 600–655.  https://doi.org/10.1007/s12124-014-9281-3CrossRefPubMedGoogle Scholar
  56. Verweij, K. J., et al. (2012). Maintenance of genetic variation in human personality: Testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding. Evolution, 66, 3238–3251.  https://doi.org/10.1111/j.1558-5646.2012.01679.xCrossRefPubMedPubMedCentralGoogle Scholar
  57. Verweij, K. J. H., et al. (2010). A genome-wide association study of Cloninger’s temperament scales: Implications for the evolutionary genetics of personality. Biological Psychology, 85, 306–317.  https://doi.org/10.1016/j.biopsycho.2010.07.018CrossRefPubMedPubMedCentralGoogle Scholar
  58. Watson, D., Clark, L. A., & Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS scale. Journal of Personality and Social Psychology, 54, 1063–1070.CrossRefGoogle Scholar
  59. Williams, S. M., & Haines, J. L. (2011). Correcting away the hidden heritability. Annals of Human Genetics, 75, 348–350.  https://doi.org/10.1111/j.1469-1809.2011.00640.x.CrossRefGoogle Scholar
  60. Wong, K. M., & Cloninger, C. R. (2010). A person-centered approach to clinical practice. Focus, 8(2), 199–215.  https://doi.org/10.1176/foc.8.2.foc199CrossRefPubMedPubMedCentralGoogle Scholar
  61. Zigmond, A. S., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67, 361–370.CrossRefGoogle Scholar
  62. Zwir, I., Arnedo, J., Del-Val, C., Pilkki-Råback, L., Konte, B., Yang, S. S., … Cloninger, C. R. (2018a). Uncovering the complex genetics of human character. Molecular Psychiatry.  https://doi.org/10.1038/s41380-018-0263-6
  63. Zwir, I., Arnedo, J., Del-Val, C., Pilkki-Råback, L., Konte, B., Yang, S. S., … Cloninger, C. R. (2018b). Uncovering the complex genetics of human temperament. Molecular Psychiatry.  https://doi.org/10.1038/s41380-018-0264-5

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Danilo Garcia
    • 1
    • 2
  • Kevin M. Cloninger
    • 1
    • 3
  • Nigel Lester
    • 1
    • 3
    • 4
  • C. Robert Cloninger
    • 1
    • 3
    • 4
  1. 1.Blekinge Center for Competence, Region BlekingeKarlskronaSweden
  2. 2.Department of PsychologyUniversity of GothenburgGothenburgSweden
  3. 3.Anthropedia FoundationSt. LouisUSA
  4. 4.Department of PsychiatryCenter for Well-Being, Washington University School of MedicineSt. LouisUSA

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