Staging of Malignant Pleural Mesothelioma

  • Patricia M. de Groot
  • Girish S. Shroff
  • Carol C. Wu
  • David R. Rice
  • Brett W. CarterEmail author


Primary malignancy of the pleura is rare and usually has a poor prognosis. Malignant pleural mesothelioma is linked to occupational and environmental exposures with a latency period of 2–6 decades. Patients usually present late in the course of the disease with chest pain, dyspnea, and weight loss. Outcomes are related to both the histological subtype of the tumor and staging at presentation. Computed tomography (CT) is the imaging modality most commonly used for preliminary noninvasive clinical staging. Magnetic resonance (MR) imaging, particularly dynamic sequences, is useful in evaluating chest wall, diaphragm, and mediastinal invasion. It can be helpful when CT findings are equivocal to distinguish resectable from unresectable disease. Positron-emission tomography (PET)/CT is performed in patients being considered for surgical resection, as it may identify nodal and/or distant metastases not seen on CT. PET/CT may also have a role in evaluation of response to treatment and detection of recurrent disease. The 8th edition of the TNM staging system is in effect as of January 1, 2018.


Malignant pleural mesothelioma Epithelioid mesothelioma Sarcomatoid mesothelioma Staging 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Patricia M. de Groot
    • 1
  • Girish S. Shroff
    • 1
  • Carol C. Wu
    • 1
  • David R. Rice
    • 2
  • Brett W. Carter
    • 1
    Email author
  1. 1.Department of Diagnostic RadiologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of Thoracic and Cardiovascular SurgeryThe University of Texas MD Anderson Cancer CenterHoustonUSA

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