Chimerism pp 105-117 | Cite as

Hematopoietic Stem Cell Donor Selection and Graft-Versus-Host Disease

  • Alexa J. Siddon
  • Christopher A. TormeyEmail author


Hematopoietic progenitor cell (HPC; stem cell) transplants represent a key management option for patients with severe disorders, particularly benign or malignant hematological diseases. However, in order to successfully perform a stem cell transplant, it is vital to determine the optimal source of HPCs to serve as a graft, as well as understand the strengths and limitations of these products. Moreover, it is important to understand the potential complications associated with HPC. As such, the aims of this chapter are as follows: (1) to review the types of stem cell sources available for transplant and how they are collected, (2) to discuss HLA and ABO compatibility in the setting of HPC transplant, (3) to understand the potential side effects of stem cell engraftment/transplantation, and (4) to assess possible treatments for side effects that pertain to transfusion medicine and apheresis services.


Hematopoietic progenitor cell transplant Stem cell transplant HLA compatibility ABO compatibility Graft-versus-host disease Donor lymphocyte infusion 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyYale University School of MedicineNew HavenUSA
  2. 2.Pathology and Laboratory Medicine Service, VA Connecticut HealthCare SystemWest HavenUSA
  3. 3.Department of Laboratory MedicineYale University School of MedicineNew HavenUSA

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