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Chimerism pp 19-31 | Cite as

Pregnancy and Multiple Gestations

  • Linda Marie Randolph
  • Ramen H. Chmait
Chapter

Abstract

Chimerism in medicine refers to harboring cells or DNA that are genetically disparate, having arisen from two separate entities, such as two zygotes or two fetuses. When the amount of at least one cell line is small, it is called microchimerism, or Mc. Microchimerism in pregnancy is common between fetus and mother and between twins, and the chimerism can be long-lasting. When assisted reproductive technology is employed, chimerism appears to be more common than otherwise in dizygotic twins. This chapter reviews postulated mechanisms and health effects of chimerism that can result. It is important to recognize chimerism as a potential confounding factor in checking zygosity during and after pregnancy, as this chapter illustrates.

Keywords

Chimerism Placenta Microchimerism Assisted reproductive technology Twin-twin transfusion Multiple gestation Twins Monochorionic Dizygotic 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Medical GeneticsChildren’s Hospital Los Angeles, University of Southern California, Keck School of MedicineLos AngelesUSA
  2. 2.Los Angeles Fetal SurgeryPasadenaUSA
  3. 3.Obstetrics and Gynecology, Pediatrics, and SurgeryUniversity of Southern California, Keck School of MedicinePasadenaUSA

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