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Stress Granules and ALS: A Case of Causation or Correlation?

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Book cover RNA Metabolism in Neurodegenerative Diseases

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 20))

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. These aggregates are linked to ALS pathogenesis. Recent evidence has suggested that stress granules may aid the formation of ALS protein aggregates. Here, we summarize current understanding of stress granules, focusing on assembly and clearance. We also assess the evidence linking alterations in stress granule formation and dynamics to ALS protein aggregates and disease pathology.

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Authors and Affiliations

  1. Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA

    Nikita Fernandes, Nichole Eshleman & J. Ross Buchan

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  1. Nikita Fernandes
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  2. Nichole Eshleman
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Correspondence to J. Ross Buchan .

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  1. Department of Neurobiology and Neurology, Dignityhealth St. Joseph’s Hospital, Barrow Neurological Institute, Phoenix, Arizona, USA

    Rita Sattler

  2. Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Christopher J. Donnelly

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Fernandes, N., Eshleman, N., Buchan, J.R. (2018). Stress Granules and ALS: A Case of Causation or Correlation?. In: Sattler, R., Donnelly, C. (eds) RNA Metabolism in Neurodegenerative Diseases. Advances in Neurobiology, vol 20. Springer, Cham. https://doi.org/10.1007/978-3-319-89689-2_7

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