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RNA Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases

  • Ashley Boehringer
  • Robert Bowser
Chapter
Part of the Advances in Neurobiology book series (NEUROBIOL, volume 20)

Abstract

In eukaryotic cells, transcription and translation are compartmentalized by the nuclear membrane, requiring an active transport of RNA from the nucleus into the cytoplasm. This is accomplished by a variety of transport complexes that contain either a member of the exportin family of proteins and translocation fueled by GTP hydrolysis or in the case of mRNA by complexes containing the export protein NXF1. Recent evidence indicates that RNA transport is altered in a number of different neurodegenerative diseases including Huntington’s disease, Alzheimer’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Alterations in RNA transport predominately fall into three categories: Alterations in the nuclear membrane and mislocalization and aggregation of the nucleoporins that make up the nuclear pore; alterations in the Ran gradient and the proteins that control it which impacts exportin based nuclear export; and alterations of proteins that are required for the export of mRNA leading nuclear accumulation of mRNA.

Keywords

RNA TREX Exportin Nuclear pore complex Amyotrophic lateral sclerosis Alzheimer’s disease Huntington’s disease Frontotemporal dementia 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurobiologyBarrow Neurological InstitutePhoenixUSA
  2. 2.School of Life SciencesArizona State UniversityPhoenixUSA

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