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RNA Editing Deficiency in Neurodegeneration

  • Ileana Lorenzini
  • Stephen Moore
  • Rita Sattler
Chapter
Part of the Advances in Neurobiology book series (NEUROBIOL, volume 20)

Abstract

The molecular process of RNA editing allows changes in RNA transcripts that increase genomic diversity. These highly conserved RNA editing events are catalyzed by a group of enzymes known as adenosine deaminases acting on double-stranded RNA (ADARs). ADARs are necessary for normal development, they bind to over thousands of genes, impact millions of editing sites, and target critical components of the central nervous system (CNS) such as glutamate receptors, serotonin receptors, and potassium channels. Dysfunctional ADARs are known to cause alterations in CNS protein products and therefore play a role in chronic or acute neurodegenerative and psychiatric diseases as well as CNS cancer. Here, we review how RNA editing deficiency impacts CNS function and summarize its role during disease pathogenesis.

Keywords

RNA editing MARCH AMPA GluA2 5HT receptors K channels Excitotoxicity Neurodegeneration Psychiatric diseases Cancer 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Ileana Lorenzini
    • 1
  • Stephen Moore
    • 1
    • 2
  • Rita Sattler
    • 3
  1. 1.Barrow Neurological Institute, Department of Neurobiology, Dignity HealthSt. Joseph’s Hospital and Medical CenterPhoenixUSA
  2. 2.Interdisciplinary Graduate Program in NeuroscienceArizona State UniversityTempeUSA
  3. 3.Department of Neurobiology and NeurologyDignityhealth St. Joseph’s Hospital, Barrow Neurological InstitutePhoenixUSA

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