Heat Shock Protein70 in Neurological Disease
The HSP70 is a chaperon protein that is expressed during stress conditions that participates in many biological processes, including protein trafficking, nascent polypeptide folding and the refolding of the wrong proteins and cleaning of the misfolded ones. The expression is increased during various pathological conditions such as cerebral ischemia, neurodegenerative diseases, epilepsy, and trauma. They are found in both intracellular and extracellular compartments. HSP70 exhibits different functions in accordance with its location. Intracellular HSP70 exerts cytoprotective functions as a chaperone protein, whereas extracellular HSP70 exerts immunomodulatory functions that trigger immunological responses. They play an auxiliary role in antigen presentation in the appearance of immunological response in multiple sclerosis. Epilepsy is thought to have emerged as a stressor. HSP overexpression is proposed as a potential therapy for neurodegenerative diseases characterized by the accumulation or aggregation of abnormal proteins. In this chapter, we wanted to summarize the recent studies on the role of HSP70 in neurological disorders.
KeywordsAlzheimer disease Heat shock protein 70 Hsp70 Neurological disorders Neuroprotection
Amyotrophic Lateral Sclerosis
Experimental allegic encephalomyelitis
Fatal familial insomnia
Heat shock protein
Leucine-rich repeat kinase-2
Mesial temporal sclerosis
PTEN-induced putative kinase 1
Cellular prion associated proteins
Disease associated prion proteins
Tar DNA binding protein 43
Variant Creutzfeldt-Jakob disease
We would like to thank the editorial staff for the opportunity of being able to be among the authors of the book.
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