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Clinical Implication of Heat Shock Protein 70 in Kidney Disease

Kidney Diseases and HSP70
  • Alev Yilmaz
  • Zeynep Nagehan Yuruk Yildirim
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 14)

Abstract

Heat shock protein (HSP) 70 has been investigated from various aspects in experimental studies, since it is the most abundant form of HSP in cells. HSP 70 is involved in response to various acute and chronic insults of kidney and also other parts of the urinary tract. Although it is not a specific biomarker for any of the kidney diseases, HSP 70 level of body fluids may be beneficial as a biomarker in some specific circumstances, for example for the differential diagnosis of “a children with fever”. The number of possible diseases in this situation is limited and an infection is most likely to be the reason of fever. Additionally, clarifying the exact role of HSP 70 in different kidney diseases enables to discover new therapeutic options in order to prevent renal fibrosis and chronic renal failure in the future. This chapter reviews experimental and clinical studies to find out the opportunities to utilize HSP 70 in daily clinical practice.

Keywords

Acute kidney diseases Biomarker Chronic kidney diseases Heat shock protein 70 HSP70 Kidney disease 

Abbreviations

AGEs

advanced glycosylated-end products

AKI

acute kidney injury

AUC

area under the curve

CKD

chronic kidney disease

CSF

cerebrospinal fluid

EMT

epithelial-mesenchymal transition

ESRD

end stage renal disease

GGA

geranylgeranylacetone

HSP

heat shock protein

IFNγ

interferon gamma

IL-18

interleukin 18

INS

idiopathic nephrotic syndrome

JAK/STAT

janus kinase/signal transducers and activators of transcription

KIM-1

kidney injury molecule type 1

MEK/ERK

Mitogen-activated protein kinase/ERK kinase/extracellular-signal-regulated kinase

NGAL

neutrophil gelatinase-associated lipocalin

NF-kB

nuclear factor kappa B

NOS

nitric oxide synthase

p-STAT3

phospho-signal transducer and activator of transcription 3

ROS

reactive oxygen species

SLK

Ste20-like kinase

STAT3

Signal transducer and activator of transcription 3

TGF-β

transforming growth factor beta

T1DM

type 1 diabetes mellitus

uHSP70

urine level of heat shock proetin 70

uHSP/Cr

urine heat shock protein/creatinine ratio

UTI

urinary tract infection

WT1

wilms tumor 1

Notes

Acknowledgements

None

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Alev Yilmaz
    • 1
  • Zeynep Nagehan Yuruk Yildirim
    • 1
  1. 1.Istanbul Faculty of Medicine, Pediatric Nephrology DepartmentIstanbul UniversityIstanbulTurkey

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