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Heat Shock Proteins in Cardiovascular Diseases: From Bench to Bedside

  • Francesca Bonomini
  • Gaia Favero
  • Valentina Trapletti
  • Rita Rezzani
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 14)

Abstract

Heat shock proteins (HSP) are stress proteins induced in response to a wide variety of physiological and environmental insults. HSP function as molecular chaperones and they are required to maintain the proteome in a folded and functional state, allowing the cells to survive stress conditions. These key proteins, which may be located intracellularly or extracellularly, have multiple functions that range from the regulation of essential cells function to the renaturation of misfolded proteins. In the last decades, the HSP involvement in both normal cell function and disease pathogenesis is widely studied, especially in the context of cardiovascular diseases (CVDs). This chapter covers the current knowledge on the function HSP in the cardiovascular system and particular in the relationship between these proteins and CVDs. Initially, the roles of HSP in cardiovascular health are outlined, followed by an evaluation of the role of HSP in CVDs key processes, such as atherosclerosis, vascular hypertrophy and heart failure. Finally, the therapeutic potential of roles HSP are examined in a CVDs context, considering how the knowledge actually gained may be capitalized in future clinical studies.

Keywords

Cardiovascular diseases Heat shock proteins Hsp40 Hsp60 Hsp70 Hsp90 Small heat shock proteins Therapeutics 

Abbreviations

AIF

apoptosis inducing factor

ApoE-/-

apolipoproteinE knock out mice

Ca2+

calcium

CEL

celastrol

CVDs

cardiovascular diseases

GGA

geranylgeranylacetone

HSEs

heat shock elements

Hsf1

heat transcription factor 1

HSP

heat shock protein

LDL-C

low-density lipoprotein-cholesterol

RIPC

remote ischemic preconditioning

ROS

reactive oxygen species

sHSP

small heat shock protein

sHSP60

soluble heat shock protein60

SMCs

smooth muscle cells

TLR4s

toll-like receptors 4

VSMCs

vascular smooth muscle cells

Notes

Acknowledgements

This study was supported by the grant (ex-60%) of the University of Brescia, Italy. The Authors sincerely thanks also Fondazione Cariplo e Regione Lombardia “New opportunities and ways towards ERC” (Project 2014-2256).

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Francesca Bonomini
    • 1
    • 2
  • Gaia Favero
    • 1
  • Valentina Trapletti
    • 1
  • Rita Rezzani
    • 1
    • 2
  1. 1.Anatomy and Physiopathology Division, Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly
  2. 2.Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs- (ARTO)”University of BresciaBresciaItaly

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