Anti-Infection Technologies for Orthopedic Implants: Materials and Considerations for Commercial Development

  • David ArmbrusterEmail author


Orthopedic implant-related infection is a difficult clinical challenge, and a common cause of implant failure. Often due to bacterial biofilms formed on the implant surface, this unmet clinical need presents an opportunity for the development of new material technologies to make orthopedic implant surfaces less hospitable to bacterial colonization. Anti-infection material technologies are divided generally into three categories: passive surface modifications, active surface modifications, and perioperative local antibiotic carriers or coatings. Significant research has been published on technologies in each of these categories, and each approach offers potential advantages. Development of any anti-infection technology in orthopedics is made more difficult by the lack of good preclinical models of implant-related infection, a complex regulatory environment, a fragmented market, and indication-specific requirements for clinical data. Successful commercialization will depend on the identification of technical solutions to these nontechnical challenges.


Infection Biofilm Orthopedic Coating Staphylococcus Bacteria Surface modification Antibiotic Antimicrobial Silver PMMA Regulatory FDA 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.DePuy Synthes Biomaterials R&DWest ChesterUSA

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