Colitis pp 1-3 | Cite as


  • Anne Jouret-MourinEmail author
  • Karel Geboes
  • Gavino Faa


The first colon fibroscope prototypes were developed in 1963 but it was not until American Cystoscope Makers Inc. entered the field in the late 1960s that clinical coloscopy began to flourish. Endoscopy presented some advantages in the ability to see variations in the color of the mucosa, visual resolution of tiny lesions, and the means to obtain tissue diagnosis. In the early 1970s, various studies demonstrated the value of coloscopy with biopsy for the differential diagnosis of inflammatory bowel diseases (IBD) [1, 2]. By the early 1980s, it became clear that the diagnosis and differential diagnosis of IBD, colitis in general, and diarrhea are indications for coloscopy and biopsy as stated in guidelines of the American Society for Gastrointestinal Endoscopy. Over the years, the number of endoscopic biopsies of the colon coming to the pathology laboratory has therefore gradually increased and today they present a daily challenge for pathologists.


  1. 1.
    Dilawari JB, Parkinson C, Riddell RH, et al. Colonoscopy in the investigation of ulcerative colitis. Gut. 1973;14:426.CrossRefPubMedGoogle Scholar
  2. 2.
    Geboes K, Vantrappen G. The value of colonoscopy in the diagnosis of Crohn’s disease. Gastrointest Endosc. 1975;22:18–23.CrossRefPubMedGoogle Scholar
  3. 3.
    Schiller LR. Diarrhea. Med Clin North Am. 2000;84:1259–74.CrossRefPubMedGoogle Scholar
  4. 4.
    Beaugerie L. Imputation des diarrhées et des entérocolites aux medicaments. Gastroenterol Clin Biol. 1991;22:773–7.Google Scholar
  5. 5.
    Whithead R. Colitis: problems in definition and diagnosis. Virchows Arch A Pathol Anat Histopathol. 1990;417:187–90.CrossRefGoogle Scholar
  6. 6.
    Marshall JB, Singh R, Diaz-Arias AA. Chronic, unexplained diarrhea: are biopsies necessary if colonoscopy is normal? Am J Gastroenterol. 1995;90:372–6.PubMedGoogle Scholar
  7. 7.
    Shah RJ, Fenoglio-Preiser C, Bleau BL, et al. Usefulness of colonoscopy with biopsy in the evaluation of patients with chronic diarrhea. Am J Gastroenterol. 2001;96:1091–5.CrossRefPubMedGoogle Scholar
  8. 8.
    Alsaigh N, Fogt F. Intestinal spirochetosis: clinicopathological features with review of the literature. Color Dis. 2002;4:97–100.CrossRefGoogle Scholar
  9. 9.
    Headstrom PD, Surawicz CM. Chronic diarrhea. Clin Gastroenterol Hepatol. 2005;3:734–7.CrossRefPubMedGoogle Scholar
  10. 10.
    Spiller RC, Jenkins D, Thornley JP, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 2004;47:804–11.CrossRefGoogle Scholar
  11. 11.
    Dickinson RJ, Gilmour HM, McClelland DB. Rectal biopsy in patients presenting to an infectious disease unit with diarrhoeal disease. Gut. 1979;20:141–8.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Elliott PR, Williams CB, Lennard-Jones JE, et al. Colonoscopic diagnosis of minimal change colitis in patients with normal sigmoidoscopy and normal air-contrast barium enema. Lancet. 1982;1(8273):650–1.CrossRefPubMedGoogle Scholar
  13. 13.
    Bryant DA, Mintz ED, Puhr ND, et al. Colonic epithelial lymhocytosis associated with an epidemic of chronic diarrhea. Am J Surg Pathol. 1996;20:1102–9.CrossRefPubMedGoogle Scholar
  14. 14.
    Geboes K, Geboes K, Jouret-Mourin A. Endoscopy and histopathology. In: Amornyotin S, editor. Endoscopy, vol. 1. Rijeka: InTech; 2013. p. 3–32. ISBN:978-953-51-1071-2.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyCliniques Universitaires St Luc, UCLBrusselsBelgium
  2. 2.Department of PathologyGhent University HospitalGhentBelgium
  3. 3.Department of PathologyKU LeuvenLeuvenBelgium
  4. 4.Division of Pathology, Department of Surgical SciencesUniversity Hospital San Giovanni di Dio, University of CagliariCagliariItaly

Personalised recommendations