Genetics in Pediatric Consultation-Liaison Psychiatry and Multidisciplinary Management of Complex Conditions

  • Branko AleksicEmail author
  • Itzel Bustos Villalobos
  • Hideki Kasuya
  • Anthony P. S. Guerrero


Pediatric consultation-liaison psychiatrists play important roles in helping healthcare teams to optimally manage complex conditions. These roles can include: helping pediatric colleagues to consider genetic and other medical etiologies for behavioral symptoms, leading and/or optimizing multidisciplinary teams in managing complex conditions, and helping families to cope with illnesses with significant impacts on well-being. In this chapter, we explore some of these roles and provide an overview of the specialized topic of psychiatric genetics, which is the topic of interest to both contemporary psychiatry and pediatrics yet often not always specifically covered in standard references for consultation-liaison psychiatry.


Genetics Behavioral Medicine Psychosomatic Child psychiatry Medicine Behavioral Referral and consultation Intersectorial collaboration Genetics Medical Genetic counseling 


  1. Appelbaum, P. S., & Benston, S. (2017). Anticipating the ethical challenges of psychiatric genetic testing. Current Psychiatry Reports, 19(7), 39.CrossRefGoogle Scholar
  2. Bamshad, M. J., Ng, S. B., Bigham, A. W., Tabor, H. K., Emond, M. J., Nickerson, D. A., & Shendure, J. (2011). Exome sequencing as a tool for Mendelian disease gene discovery. Nature Reviews. Genetics, 12(11), 745–755.CrossRefGoogle Scholar
  3. Butler, M. G., Manzardo, A. M., & Forster, J. L. (2016). Prader-Willi syndrome: Clinical genetics and diagnostic aspects with treatment approaches. Current Pediatric Reviews, 12(2), 136–166.CrossRefGoogle Scholar
  4. Demkow, U., & Wolanczyk, T. (2017). Genetic tests in major psychiatric disorders-integrating molecular medicine with clinical psychiatry-why is it so difficult? Translational Psychiatry, 7(6), e1151.CrossRefGoogle Scholar
  5. Gelernter, J. (2015). Genetics of complex traits in psychiatry. Biological Psychiatry, 77(1), 36–42.CrossRefGoogle Scholar
  6. Holm, V. A., Cassidy, S. B., Butler, M. G., Hanchett, J. M., Greenswag, L. R., Whitman, B. Y., & Greenberg, F. (1993). Prader-Willi syndrome: Consensus diagnostic criteria. Pediatrics, 91(2), 398–402.PubMedGoogle Scholar
  7. McClellan, J., & King, M. C. (2010). Genetic heterogeneity in human disease. Cell, 141(2), 210–217.CrossRefGoogle Scholar
  8. O'Donovan, M. C., & Owen, M. J. (2016). The implications of the shared genetics of psychiatric disorders. Nature Medicine, 22(11), 1214–1219.CrossRefGoogle Scholar
  9. Pritchard, J. K. (2001). Are rare variants responsible for susceptibility to complex diseases? American Journal of Human Genetics, 69(1), 124–137.CrossRefGoogle Scholar
  10. Reich, D. E., & Lander, E. S. (2001). On the allelic spectrum of human disease. Trends in Genetics, 17(9), 502–510.CrossRefGoogle Scholar
  11. Richter, J. D., Bassell, G. J., & Klann, E. (2015). Dysregulation and restoration of translational homeostasis in fragile X syndrome. Nature Reviews Neuroscience, 16(10), 595–605.CrossRefGoogle Scholar
  12. Uher, R. (2014). Gene-environment interactions in common mental disorders: An update and strategy for a genome-wide search. Social Psychiatry and Psychiatric Epidemiology, 49(1), 3–14.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Branko Aleksic
    • 1
    Email author
  • Itzel Bustos Villalobos
    • 1
    • 2
  • Hideki Kasuya
    • 1
    • 2
  • Anthony P. S. Guerrero
    • 2
  1. 1.Office of international affairsNagoya University, Graduate School of MedicineNagoyaJapan
  2. 2.Department of PsychiatryUniversity of Hawai‘i John A. Burns School of MedicineHonoluluUSA

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