Inflammasome in the Pathogenesis of Pulmonary Diseases

  • Fengying Xu
  • Zongmei Wen
  • Xueying Shi
  • Jie FanEmail author
Part of the Experientia Supplementum book series (EXS, volume 108)


Lung diseases are common and significant causes of illness and death around the world. Inflammasomes have emerged as an important regulator of lung diseases. The important role of IL-1 beta and IL-18 in the inflammatory response of many lung diseases has been elucidated. The cleavage to turn IL-1 beta and IL-18 from their precursors into the active forms is tightly regulated by inflammasomes. In this chapter, we structurally review current evidence of inflammasome-related components in the pathogenesis of acute and chronic lung diseases, focusing on the “inflammasome-caspase-1-IL-1 beta/IL-18” axis.


Inflammasomes Infectious pulmonary diseases Lung injury Smoking Chronic obstructive pulmonary disease 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Fengying Xu
    • 1
    • 4
  • Zongmei Wen
    • 2
  • Xueying Shi
    • 3
  • Jie Fan
    • 4
    • 5
    Email author
  1. 1.Department of AnesthesiologyNo. 401 HospitalQingdaoChina
  2. 2.Department of Anesthesiology, Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina
  3. 3.Department of Anesthesiology and Critical Care, Shanghai Xinghua HospitalJiaotong University School of MedicineShanghaiChina
  4. 4.Department of SurgeryUniversity of Pittsburgh School of MedicinePittsburghUSA
  5. 5.Research and Development, Veterans Affairs Pittsburgh Healthcare SystemPittsburghUSA

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