Genetics of Inflammasomes

Part of the Experientia Supplementum book series (EXS, volume 108)


Mutations in inflammasome genes are responsible for rare monogenic and polygenic autoinflammatory diseases. On the other side, genetic polymorphisms in the same molecules contribute to the development of common multifactorial diseases (i.e., autoimmune diseases, cardiovascular pathologies, cancer). In this chapter we depicted the current knowledge about inflammasome genetics.


Polymorphisms Inflammasome IL-1β IL-18 Autoinflammatory syndromes Multifactorial diseases 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clinicas HCFMUSP, Faculdade de MedicinaUniversidade de São PauloSão PauloBrasil
  2. 2.Avenida Dr. Enéas de Carvalho Aguiar, 470 – Instituto de Medicina Tropical (IMT) Prédio 2 – 3° andarSão PauloBrasil
  3. 3.Laboratório de Imunogenética, Departamento de ImunologiaInstituto de Ciências Biomédicas, Universidade de São PauloSão PauloBrasil
  4. 4.Avenida Prof. Lineu Prestes, 1730 – 05508-000 Cidade UniversitáriaSão PauloBrasil

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