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Inflammasomes in Clinical Practice: A Brief Introduction

  • Elísabet Alcocer-Gómez
  • Beatriz Castejón-Vega
  • Macarena López-Sánchez
  • Mario D. Cordero
Chapter
Part of the Experientia Supplementum book series (EXS, volume 108)

Abstract

Inflammasomes are multiprotein complexes formed and activated after exposure to pathogenic microbes and host danger signals that control the maturation and production of IL-1β and IL-18. Their implication in different diseases such as cardiovascular, neurodegenerative, psychiatric, and metabolic diseases opens a door to developing new therapeutic perspectives. However, the rapid increase in the knowledge about inflammasomes is associated with their involvement in clinical practice. Two topics open the way to future lines of research: a clinical trial with the new specific inhibitors and the development of diagnostic tools.

Keywords

Inflammasomes NLRP3 Clinical medicine Diagnosis Pharmacological treatment 

References

  1. Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet T, Rouis M (2015) NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biol 4:296–307CrossRef