Exposome appears as a very promising tool for better understanding the complexity of interactions between genome and environment, especially when investigating large population studies. The HEALS project aims at identifying the complex links among genes, environment, and human disease on allergies and asthma, neurodevelopmental/neurodegenerative and metabolic disorders based on individual exposome characterization and how should this be implemented in large cohorts. HEALS relies on the re-analysis of existing cohort studies and the deployment of a Pilot European Exposure and Health Examination Survey. Although the analysis will start from the collection of biomonitoring data, a wide array of omics technologies (completed by confirmatory in vitro testing) will be employed. Lifetime exposure assessment will involve novel technologies such as sensors and agent- based modelling. Mapping the different omics responses onto regulatory networks and disease pathways will allow understanding the intermediate stages from exposure to disease at individual as well as population level. HEALS is expected to provide additional insights into the way to synthesize different data and methodological tools for assessing the internal and external exposome overall aiming to a better understanding of both the potential mechanisms and the origin of disease. This includes (1) how different environmental factors contribute cumulatively to disease and (2) the common nodes of exposure and molecular events resulting in phenomenally different health outcomes. HEALS is a comprehensive methodological advance aiming to provide the way of linking interdisciplinary research towards the understanding of genome and lifetime environmental interaction at individual and population level.
KeywordsLife-time exposure assessment Agent-based modelling
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