Oesophagus: Neoplastic Patterns and Mimics

  • M. Priyanthi KumarasingheEmail author
  • Benjamin M. Allanson
  • Spiro C. Raftopoulos
  • Gregory Y. Lauwers


One of the most common challenges confronted by pathologists in assessing esophageal biopsies is suspected esophageal neoplasia. This chapter elaborates the clinical setting leading to biopsy and provides the general approach to esophageal biopsy with emphasis on epithelial patterns. Common patterns of mesenchymal neoplasia are also touched on. The patterns of squamous and glandular dysplasia relevant for accurate and reproducible diagnosis are discussed in detail including features relevant to grading, identification of invasion, benign mimics, and diagnostic pitfalls. The key features are highlighted. Important concepts are further illustrated by short clinical stories that correlate important clinical, endoscopic, and pathologic features. Helpful diagnostic features are demonstrated and described with high-quality photomicrographs and accompanying descriptions.


Neoplastic patterns Mimics Esophageal biopsy Epithelial patterns Mesenchymal neoplasia Squamous dysplasia Glandular dysplasia Intramucosal carcinoma Foveolar and Intestinal phenotype dysplasia p53 abberent expression Invasion 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • M. Priyanthi Kumarasinghe
    • 1
    Email author
  • Benjamin M. Allanson
    • 2
    • 3
  • Spiro C. Raftopoulos
    • 4
    • 5
  • Gregory Y. Lauwers
    • 6
  1. 1.Department of Anatomical Pathology, PathWest Laboratory MedicineQEII Medical Centre and University of Western AustraliaPerthAustralia
  2. 2.Department of Tissue Pathology and Diagnostic OncologyRoyal Prince Alfred Hospital and School of Pathology and Laboratory MedicineSydneyAustralia
  3. 3.University of Western AustraliaPerthAustralia
  4. 4.Interventional Endoscopist and Gastroenterologist, Department of GastroenterologySir Charles Gairdner HospitalNedlandsAustralia
  5. 5.University of Western AustraliaPerthAustralia
  6. 6.Gastrointestinal Pathology Service, Department of PathologyMoffitt Cancer CenterTampaUSA

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