Natural History

  • Qin Huang
  • Lily Huang


Based on the results of a few small, but extremely valuable, case-series studies on the natural history of gastric cardiac carcinoma in China and Japan, gastric cardiac carcinoma is a slow-progressive malignant neoplasm, taking 2–6 years to progress from intramucosa to submucosa. However, once invading into the muscularis propria, the tumor becomes much more aggressive. Therefore, the patient management may need to be individualized, according to the specific stage of the disease.


Gastric cardiac carcinoma Stomach Natural history Cancer Early gastric carcinoma 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Qin Huang
    • 1
    • 2
  • Lily Huang
    • 3
  1. 1.Pathology and Laboratory MedicineVeterans Affairs Boston Healthcare SystemWest RoxburyUSA
  2. 2.Harvard Medical School and Brigham and Women’s HospitalBostonUSA
  3. 3.Beth Israel Deaconess Medical CenterBostonUSA

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