Khat—A Natural Source of Cathinone

Chapter
Part of the Current Topics in Neurotoxicity book series (Current Topics Neurotoxicity, volume 12)

Abstract

Recently, a class of new psychoactive substances (NPS) has appeared as drugs of abuse. NPS comprise different drug classes; the most popular are synthetic cannabinomimetics and designer analogues of cathinone, an intermediate metabolite in a biosynthetic pathway, and a psychostimulant, found in the plants Catha edulis Forsk., Ephedra gerardiana sikkimensis, and Ephedra sinica. In C. edulis and E. gerardiana sikkimensis, cathinone is converted to norpseudoephedrine (cathine) and norephedrine, while in E. sinica the pathway continues to pseudoephedrine and ephedrine. While cathinone analogues are used for recreational purposes, cathinone, itself, is consumed only through chewing khat, i.e., the fresh leaves and twigs of the plant C. edulis Forsk., a practice similar to chewing of coca leaves. The use of khat is common among people living in Southwestern Arabia and Eastern Africa with an estimated 10–20 million daily users. This chapter describes the use of khat, its distribution and cultivation, the biosynthetic pathway that involves cathinone, the long delay in the discovery of cathinone, the neurochemistry of khat and cathinone, its effects on humans, and its dependency and addiction potential.

Keywords

Khat Cathinone Novel psychoactive substances Catha edulis Forsk Ephedra gerardiana sikkimensis Ephedra sinica 

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medical Physiology, School of MedicineCollege of Health Sciences, University of NairobiNairobiKenya

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