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A Child with Papillary Thyroid Carcinoma: Role of Radioactive Iodine Therapy in Pediatric Patients

  • Çiğdem Soydal
  • Elgin Özkan
Chapter

Abstract

A 13-year-old girl with a family history of thyroid carcinoma underwent thyroid ultrasound. A hypoechoic thyroid nodule with a 4 cm diameter was detected on the right thyroid lobe accompanying enlarged central compartment lymph nodes. Thus, the patient underwent total thyroidectomy and bilaterally central compartment lymph node dissection. Pathological examination revealed a conventional subtype papillary thyroid carcinoma located on the right thyroid lobe with a 4 cm diameter. Contrast-enhanced tomography of the thorax showed multiple metastatic nodules in both lungs. The patient was referred for radioiodine treatment (RAT) with a T3N1aM1 tumor. During radioiodine treatment, serum thyroglobulin (Tg) levels were measured as >472 ng/ml. Posttreatment I-131 whole-body scintigraphy showed multiple radioactivity accumulations in the neck and both hemithoraces.

Keywords

Pediatric thyroid carcinoma Radioiodine treatment Lung metastases 

References

  1. 1.
    Verburg FA, Van Santen HM, Luster M. Pediatric papillary thyroid cancer: current management challenges. Onco Targets Ther. 2016;28:165–75.  https://doi.org/10.2147/OTT.S100512.CrossRefGoogle Scholar
  2. 2.
    Rapkin L, Pashankar FD. Management of thyroid carcinoma in children and young adults. J Pediatr Hematol Oncol. 2012;34:39–46.  https://doi.org/10.1097/MPH.0b013e31824e37a6.CrossRefGoogle Scholar
  3. 3.
    Hung W, Sarlis NJ. Current controversies in the management of pediatric patients with well-differentiated nonmedullary thyroid cancer: a review. Thyroid. 2002;12:683–702.  https://doi.org/10.1089/105072502760258668.CrossRefPubMedGoogle Scholar
  4. 4.
    Ying AK, Huh W, Bottomley S, Evans DB, Waguespack SG. Thyroid cancer in young adults. Semin Oncol. 2009;36:258–74.  https://doi.org/10.1053/j.seminoncol.2009.03.009.CrossRefPubMedGoogle Scholar
  5. 5.
    Hogan AR, Zhuge Y, Perez EA, Koniaris LG, Lew JI, Sola JE. Pediatric thyroid carcinoma: incidence and outcomes in 1753 patients. J Surg Res. 2009;156:167–72.  https://doi.org/10.1016/j.jss.2009.03.098.CrossRefPubMedGoogle Scholar
  6. 6.
    Shapiro NL, Bhattacharyya N. Population-based outcomes for pediatric thyroid carcinoma. Laryngoscope. 2005;115:337–40.  https://doi.org/10.1097/01.mlg.0000154743.71184.09.CrossRefPubMedGoogle Scholar
  7. 7.
    Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, et al. Management guidelines for children with thyroid nodules and differentiated thyroid cancer.; American Thyroid Association guidelines task force. Thyroid. 2015;25:716–59.  https://doi.org/10.1089/thy.2014.0460.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Brink JS, van Heerden JA, McIver B, Salomao DR, Farley DR, Grant CS, et al. Papillary thyroid cancer with pulmonary metastases in children: long-term prognosis. Surgery. 2000;128(6):881.  https://doi.org/10.1067/msy.2000.109728.CrossRefPubMedGoogle Scholar
  9. 9.
    Jarzab B, Handkiewicz-Junak D. Differentiated thyroid cancer in children and adults: same or distinct disease? Hormones (Athens). 2007;6:200–9.Google Scholar
  10. 10.
    Rachmiel M, Charron M, Gupta A, Hamilton J, Wherrett D, Forte V, et al. Evidence-based review of treatment and follow up of pediatric patients with differentiated thyroid carcinoma. J Pediatr Endocrinol Metab. 2006;19:1377–93.PubMedGoogle Scholar
  11. 11.
    Thompson GB, Hay ID. Current strategies for surgical management and adjuvant treatment of childhood papillary thyroid carcinoma. World J Surg. 2004;28:1187–98.  https://doi.org/10.1007/s00268-004-7605-z.CrossRefPubMedGoogle Scholar
  12. 12.
    Rubino C, de Vathaire F, Dottorini ME, Hall P, Schvartz C, Couette JE, et al. Second primary malignancies in thyroid cancer patients. Br J Cancer. 2003;89:1638–44.  https://doi.org/10.1038/sj.bjc.6601319.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Çiğdem Soydal
    • 1
  • Elgin Özkan
    • 2
  1. 1.Department of Nuclear MedicineAnkara University School of MedicineAnkaraTurkey
  2. 2.Department of Nuclear MedicineMedical Faculty of Ankara UniversityAnkaraTurkey

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