Concurrent Papillary Thyroid Cancer and Medullary Thyroid Cancer
Concurrent occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in a single patient is uncommon. The cell origin, histopathologic features, and prognosis of these two carcinomas are considered completely different. A 40-year-old man was diagnosed MTC after fine needle aspiration biopsy of the right thyroid nodule and the lymph node on the right side. The patient underwent total thyroidectomy with unilateral central compartment and right lateral neck dissection. Histopathological evaluation was identified as MTC in the nodule of the right lobe and the MTC metastasis in the lymph nodes. Besides, papillary microcarcinoma foci were determined on the same thyroid lobe. He had c.1585 > A (p.Glu529Lys) heterozygous variant mutation of RET proto-oncogene. Sixteen months after the operation, his serum calcitonin, carcinoembryonic antigen (CEA), and thyroglobulin levels are undetectable.
KeywordsMedullary thyroid carcinoma Papillary thyroid carcinoma Concurrent medullary Papillary thyroid carcinoma
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