Targeted Systemic Therapy May Be Promising in Radioiodine-Refractory Differentiated Thyroid Cancer

  • Zehra Özcan
  • Ülkem Yararbaş


During the follow-up of a patient with differentiated thyroid carcinoma, Tg elevation without iodine uptake on WB scan was noted. She received an empiric dose of radioiodine to evaluate the possible Tg production site; however, no evidence of uptake was found. PET/CT scan showed pulmonary nodules, some of which were FDG avid. Finally, sorafenib treatment was initiated which is currently at the 22nd month of the follow-up.


Advanced thyroid cancer Rising thyroglobulin Negative iodine scan Targeted therapy Tyrosine kinase inhibitors Sorafenib 


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© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Zehra Özcan
    • 1
  • Ülkem Yararbaş
    • 1
  1. 1.Department of Nuclear MedicineEge University School of MedicineIzmirTurkey

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