Targeted Systemic Therapy May Be Promising in Radioiodine-Refractory Differentiated Thyroid Cancer
During the follow-up of a patient with differentiated thyroid carcinoma, Tg elevation without iodine uptake on WB scan was noted. She received an empiric dose of radioiodine to evaluate the possible Tg production site; however, no evidence of uptake was found. PET/CT scan showed pulmonary nodules, some of which were FDG avid. Finally, sorafenib treatment was initiated which is currently at the 22nd month of the follow-up.
KeywordsAdvanced thyroid cancer Rising thyroglobulin Negative iodine scan Targeted therapy Tyrosine kinase inhibitors Sorafenib
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