Rosiglitazone Effect on Radioiodine Uptake in a Case of Dedifferentiated Thyroid Carcinoma

  • Gülin Uçmak
  • Burcu Esen Akkaş


Differentiated thyroid cancer may lose its differential characteristics and transform to a less-differentiated form that does not concentrate radioiodine. These tumors represent an aggressive tumor type and may necessitate alternative therapies. Various attempts have been made to augment iodine uptake and to redifferentiate tumors in order to regain benefit from radioiodine therapy. Thiazolidinediones, such as rosiglitazone, act by binding to peroxisome proliferator-activated receptors (PPARs) and have also shown promise in the redifferentiation treatment of dedifferentiated thyroid carcinomas as antiproliferative and apoptosis-inducing agents. In this section, the effect of rosiglitazone is discussed in a case with dedifferentiated thyroid cancer.


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© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Gülin Uçmak
    • 1
  • Burcu Esen Akkaş
    • 1
  1. 1.Department of Nuclear MedicineUniversity of Health Sciences (SBÜ) Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalAnkaraTurkey

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