Fibrin Injection in a Hemorrhagic Cystic Thyroid Nodule

  • Haluk B. Sayman


In this case report, a new technique to be used in the treatment of hemorrhagic cystic thyroid nodules among the other historical therapeutical modalities was described. A two-component fibrin sealant, which contains two of the proteins—fibrinogen and thrombin—that make blood clot, was introduced into cyst cavity after punction by a syringe under ultrasonography guidance.

The follow-up ultrasonographies consequently showed the significant volumetric regression of the cyst in time. Hence, this method is recommended for the treatment of hemorrhagic cystic thyroid nodules as an alternative modality.


Thyroid Cyst Nodule Hemorrhagic Fibrin 


  1. 1.
    Massoll N, Nizam MS, Mazzaferri EL. Cystic thyroid nodules: diagnostic and therapeutic dilemmas. Endocrinologist. 2002;12:185–98.CrossRefGoogle Scholar
  2. 2.
    Frates MC, Benson CB, Doubilet PM, Kunreuther E, Contreras M, Cibas ES, et al. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endocrinol Metab. 2006;91:3411–7. Scholar
  3. 3.
    Lee MJ, Kim EK, Kwak JY, Kim MJ. Partially cystic thyroid nodules on ultrasound: probability of malignancy and sonographic differentiation. Thyroid. 2009;19:341–6. Scholar
  4. 4.
    Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. American Thyroid Association (ATA) guidelines taskforce on thyroid nodules and differentiated thyroid Cancer, revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214. Scholar
  5. 5.
    Rosen IB, Provias JP, Walfish PG. Pathologic nature of cystic thyroid nodules selected for surgery by needle aspiration biopsy. Surgery. 1986;100:606–13.PubMedGoogle Scholar
  6. 6.
    de los Santos ET, Keyhani-Rofagha S, Cunningham JJ, Mazzaferri EL. Cystic thyroid nodules. The dilemma of malignant lesions. Arch Intern Med. 1990;150:1422–7.CrossRefGoogle Scholar
  7. 7.
    Melliere D, Massin JP, Calmettes C, Chigot JP, Savoie JC, Arnier H. The risk of malignancy in cold thyroid nodules. 607 operated cases. Presse Med. 1970;78:311–4.PubMedGoogle Scholar
  8. 8.
    McCowen KD, Reed JW, Fariss BL. The role of thyroid therapy in patients with thyroid cysts. Am J Med. 1980;68:853–5.CrossRefGoogle Scholar
  9. 9.
    Del Prete S, Caraglia M, Russo D, Vitale G, Giuberti G, Marra M, et al. Percutaneous ethanol injection efficacy in the treatment of large symptomatic thyroid cystic nodules: ten-year follow-up of a large series. Thyroid. 2002;12:815–21. Scholar
  10. 10.
    Treece GL, Georgitis WJ, Hofeldt FD. Resolution of recurrent thyroid cysts with tetracycline instillation. Arch Intern Med. 1983;143:2285–7.CrossRefGoogle Scholar
  11. 11.
    Hegedüs L, Hansen JM, Karstrup S, Torp-Pedersen S, Juul N. Tetracycline for sclerosis of thyroid cysts a randomized study. Arch Intern Med. 1988;148:1116–8.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Haluk B. Sayman
    • 1
  1. 1.Nuclear Medicine, Cerrahpaşa Medical FacultyIstanbul UniversityIstanbulTurkey

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