Dermoscopy can improve the diagnostic accuracy and sensitivity, without decreased specificity, for melanoma when compared to naked eye examination alone. Furthermore, dermoscopy reduces the number of unnecessary biopsies of benign lesions for every malignant diagnosis. In addition, dermoscopy monitoring of melanocytic lesions enables the diagnosis of thinner melanomas. These improvements in screening and management of lesions can result in reduced morbidity, earlier diagnosis of melanoma, and increased cost-effectiveness. Several dermoscopy features including atypical pigment network, angulated lines, negative pigment network, atypical dots, atypical globules, irregular streaks, shiny white lines, irregular blotch, blue-white veil, regression structures, polymorphous vasculature, and peripheral tan structureless areas have been shown to be specific to melanoma. While incorporating dermoscopy into clinical practice is associated with a learning curve, new users may utilize diagnostic and management algorithms, such as triage amalgamated dermoscopy algorithm (TADA) or two-step algorithm, to triage lesions for further evaluation and to improve their sensitivity for diagnosing melanoma.
Melanoma Melanocytic nevus Pigmented Nevi Dermoscopy Dermatoscopy Epiluminescence Two-step TADA
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Funding: This research was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748.
Conflict of interest: The authors have no conflicts of interest to declare.
Permissions: Natalia Jaimes, M.D., has granted us permission to use select schematics throughout this chapter. Natalia Jaimes, M.D., and we retain the copyright to any line drawing included in this submission.
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