Melanoma pp 525-531 | Cite as

Chemotherapy and Biochemotherapy for Melanoma

  • Chia-Yen HungEmail author
  • John Wen-Cheng Chang


The incidence of melanoma is increasing around the world, with the majority of patients diagnosed with a localized disease. Surgical treatment remains the preferred treatment method for localized diseases. However, high-risk patients have been found to have a high risk of recurrence and distant metastasis, including stage IIB (depth > 4 mm) and stage III patients (subclinically or clinically positive regional lymph node involvement). For such patients, the recommendations are for adjuvant therapy, in order to decrease the likelihood of developing distant metastatic disease. Effective agents include high-dose interferon-alpha (IFNα), pegylated IFNα, and ipilimumab, all of which are FDA approved. Other options may include biochemotherapy with cisplatin, vinblastine, dacarbazine, interleukin-2 (IL-2) and IFNα. Several novel agents, including immune checkpoint inhibitors and targeted therapies, have significantly increased survival rates in unresectable, locally advanced and metastatic melanoma patients. Cytotoxic chemotherapy or immunotherapy with IL-2 or tumor necrosis factor-alpha (TNFα) have recently been utilized as salvage therapy for those patient unresponsive to other forms of treatment. However, (bio)chemotherapy still plays an important role in the adjuvant treatment for many patients with advanced melanoma.


Melanoma Chemotherapy Biochemotherapy Immunotherapy Management 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Hematology and Oncology Division, Internal Medicine DepartmentMackay Memorial Hospital, TaipeiNew TaipeiTaiwan
  2. 2.Division of Hematology and Oncology, Department of Internal MedicineChang Gung Memorial Hospital at Linkou, TaoyuanTaoyuanTaiwan

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