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Chemical Liposculpture of the Chin

  • Valerie D. CallenderEmail author
  • Jessica A. McCarrick
Chapter
  • 13 Downloads

Abstract

ATX-101, deoxycholic acid injection (DCA), is indicated for cosmetic reduction of moderate to severe submental fat. It works by inducing adipocytolysis and recruitment of neutrophils, macrophages, and fibroblasts, leading to long-lasting fat reduction and mild improvement in skin laxity through neocollagenesis. Procedure-specific side effects, which include submental alopecia, marginal mandibular nerve injury, and dysphagia, are both mild and transient. ATX-101 offers a pharmacologic, minimally invasive alternative to liposuction and other invasive surgical techniques in the treatment/reduction of undesired submental fat and improvement in submental profile.

References

  1. 1.
    Shamban AT. Noninvasive submental fat compartment treatment. Plast Reconstr Surg Glob Open. 2016;4(12 Suppl Anatomy and Safety in Cosmetic Medicine: Cosmetic Bootcamp):e1155.CrossRefGoogle Scholar
  2. 2.
    Jones DH, Kenkel JM, Fagien S, Glaser DA, Monheit GD, Stauffer K, Sykes JM. Proper technique for administration of ATX-101 (deoxycholic acid injection): insights from an injection practicum and roundtable discussion. Dermatol Surg. 2016;42(Suppl 1):275–81.CrossRefGoogle Scholar
  3. 3.
    U.S. Food and Drug Administration. Kybella full prescribing information. 2015. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/206333Orig1s000lbl.pdf. Accessed 18 Apr 2017.
  4. 4.
    Fagien S, McChesney P, Subramanian M, Jones DH. Prevention and management of injection-related adverse effects in facial aesthetics: considerations for ATX-101 (deoxycholic acid injection) treatment. Dermatol Surg. 2016;42(Suppl 1):300–4.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Callender Dermatology and Cosmetic CenterGlenn DaleUSA
  2. 2.Department of DermatologyHoward University HospitalWashingtonUSA

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